SUPERFAMILY 1.75 HMM library and genome assignments server

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Translin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Translin [ 74784]
Families:   Translin [ 74785]

Superfamily statistics
Genomes (526) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,012 2,867 2
Proteins 998 2,842 2

Functional annotation
General category Information
Detailed category RNA processing

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.0024490.007477Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0024960.006999Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0046080.01138Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.0051340.01371Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.0099910.09102Least InformativeInherited
Biological Process (BP)primary metabolic process0.14040.3191Least InformativeInherited
Molecular Function (MF)binding0.00011910.009217Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.000000000041660.000004163Moderately InformativeDirect
Molecular Function (MF)macromolecular complex binding0.0000046040.00003081InformativeDirect
Molecular Function (MF)DNA binding0.0016040.02899InformativeInherited
Molecular Function (MF)single-stranded DNA binding0.0000088240.00000009886Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.007477 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.006999 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01138 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.01371 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.09102 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.3191 Least Informative Inherited
Molecular Function (MF) binding 0.009217 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.000004163 Moderately Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00003081 Informative Direct
Molecular Function (MF) DNA binding 0.02899 Informative Inherited
Molecular Function (MF) single-stranded DNA binding 0.00000009886 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.0009306Least InformativeDirect
Post-translational modificationHydrolase0.00142Least InformativeInherited
Post-translational modificationDNA-binding0.00000000000001335Moderately InformativeDirect
Post-translational modificationNuclease0.000000002248Moderately InformativeDirect
Post-translational modificationRNA-binding0.000007775Moderately InformativeDirect
Post-translational modificationEndonuclease0.0000000001473InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002848 SSF74784 Protein matches

Translins are DNA-binding proteins that specifically recognise consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. They seem to recognise single-sranded DNA ends generated by staggered breaks occuring at recombination hot spots [PubMed9013868].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Translin domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Translin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]