SUPERFAMILY 1.75 HMM library and genome assignments server

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Cullin repeat-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Cullin repeat-like [ 74788] (2)
Families:   Cullin repeat [ 74789] (2)
  Exocyst complex component [ 140851] (2)


Superfamily statistics
Genomes (508) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,129 17,538 6
Proteins 7,008 17,323 6


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.03843Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1252Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.006561Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.01208Moderately InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.0008305InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.01739InformativeInherited
Mammalian Phenotype (MP)abnormal embryo development0.2527InformativeInherited
Mammalian Phenotype (MP)abnormal embryo size0.0004339Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gastrulation0.0008087Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00002957Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0009659Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003736Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.00000109Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.00003929Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.001763Moderately InformativeInherited
Worm Phenotype (WP)protein interaction variant0.07167Moderately InformativeInherited
Worm Phenotype (WP)accumulated germline cell corpses0.000000001388InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0.000000009693InformativeDirect
Worm Phenotype (WP)life span variant0.0004044InformativeDirect
Worm Phenotype (WP)apoptosis increased0.0000000000539Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.000002496Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)somatic precursor cell0Moderately InformativeDirect
Fly Anatomy (FA)female germline cyst0.0009943InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.01409Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.4171Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.5597Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.7477Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.00000004726InformativeDirect
Plant ANatomical entity (PAN)root tip0.000002419InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.00007253InformativeDirect
Plant ANatomical entity (PAN)primordium0.0001798InformativeDirect
Plant ANatomical entity (PAN)lateral root primordium0.000004274Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem0.00005329Highly InformativeDirect
Plant ANatomical entity (PAN)root stele0.0000548Highly InformativeDirect
Plant ANatomical entity (PAN)root hair cell0.0001025Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05833Highly InformativeInherited

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin repeat-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Cullin repeat-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]