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Cullin repeat family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Cullin repeat-like [ 74788] (2)
Family:   Cullin repeat [ 74789] (2)


Family statistics
Genomes (464) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,334 5,392 4
Proteins 2,318 5,363 4


Gene Ontology (high-coverage)

(
show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.00000000000003088 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000000000009365 Least Informative Direct
Biological Process (BP) primary metabolic process 0.000000002741 Least Informative Direct
Biological Process (BP) biological regulation 0.0006489 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.05696 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04719 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 0.0000000000002823 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000000008703 Moderately Informative Direct
Biological Process (BP) cellular protein metabolic process 0.0000001734 Moderately Informative Direct
Biological Process (BP) macromolecule modification 0.00006691 Moderately Informative Direct
Biological Process (BP) reproduction 0.0006608 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.1419 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3769 Moderately Informative Inherited
Biological Process (BP) regulation of primary metabolic process 0.002988 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.09863 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule metabolic process 0.6465 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.02705 Moderately Informative Inherited
Biological Process (BP) transport 0.9243 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01152 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.3819 Moderately Informative Inherited
Biological Process (BP) negative regulation of biological process 0.01794 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4995 Moderately Informative Inherited
Biological Process (BP) response to stress 0.0101 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6091 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02927 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.42 Moderately Informative Inherited
Biological Process (BP) cellular response to stimulus 0.03704 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.2364 Moderately Informative Inherited
Biological Process (BP) cell communication 0.2532 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00000000000000307 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0.00000000000000307 Informative Direct
Biological Process (BP) regulation of cell cycle 0.000000000000005999 Informative Direct
Biological Process (BP) cell cycle 0.0000000000009208 Informative Direct
Biological Process (BP) proteolysis 0.0000007952 Informative Direct
Biological Process (BP) embryo development 0.000008955 Informative Direct
Biological Process (BP) chromosome organization 0.0002771 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0007187 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.000822 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000841 Informative Direct
Biological Process (BP) regulation of organelle organization 0.08826 Informative Inherited
Biological Process (BP) intracellular transport 0.002371 Informative Inherited
Biological Process (BP) actin filament-based process 0.004317 Informative Inherited
Biological Process (BP) single-organism organelle organization 0.01843 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01399 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.001251 Informative Inherited
Biological Process (BP) protein complex assembly 0.1719 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.003772 Informative Inherited
Biological Process (BP) membrane organization 0.006365 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.02243 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.02524 Informative Inherited
Biological Process (BP) single organism reproductive process 0.00425 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.02158 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.007888 Informative Inherited
Biological Process (BP) sexual reproduction 0.07815 Informative Inherited
Biological Process (BP) cell development 0.1437 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.09394 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) protein catabolic process 0 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00000005814 Highly Informative Direct
Biological Process (BP) regulation of chromosome segregation 0.0000001373 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.000000222 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0000002453 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle 0.0000005784 Highly Informative Direct
Biological Process (BP) nuclear division 0.00000146 Highly Informative Direct
Biological Process (BP) vesicle organization 0.000001586 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.000008439 Highly Informative Direct
Biological Process (BP) cell division 0.0000102 Highly Informative Direct
Biological Process (BP) mitotic cell cycle process 0.0000603 Highly Informative Direct
Biological Process (BP) programmed cell death 0.00009338 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0001255 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0001672 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.0004781 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 0.0008657 Highly Informative Direct
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.02379 Highly Informative Inherited
Biological Process (BP) regulation of mitotic nuclear division 0.1343 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.004294 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.01294 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.0000159 Least Informative Direct
Molecular Function (MF) binding 0.0000306 Least Informative Direct
Molecular Function (MF) protein binding 0.000000007876 Moderately Informative Direct
Molecular Function (MF) enzyme binding 0.00006207 Informative Direct
Cellular Component (CC) macromolecular complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.8467 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.2295 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.254 Least Informative Inherited
Cellular Component (CC) catalytic complex 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.02119 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0003181 Informative Direct
Cellular Component (CC) supramolecular polymer 0.0009941 Informative Direct
Cellular Component (CC) cytoskeletal part 0.021 Informative Inherited
Cellular Component (CC) spindle 0.000000246 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.4692Least InformativeInherited
Biological processCell cycle0.0000007369Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processER-Golgi transport0.000000000002361Highly InformativeDirect
Cellular componentNucleus0.00000008097Least InformativeDirect
Coding sequence diversityAlternative splicing0.0006402Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cullin repeat-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]