SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Lamin A/C globular tail domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Lamin A/C globular tail domain [ 74853]
Families:   Lamin A/C globular tail domain [ 74854]


Superfamily statistics
Genomes (565) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,459 16,752 3
Proteins 1,361 13,089 3


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of central motor function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0Moderately InformativeDirect
Phenotypic Abnormality (PA)Hearing impairment0InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Global developmental delay0InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal head morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0InformativeDirect
Mammalian Phenotype (MP)abnormal spinal nerve morphology0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal diaphragm morphology0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0004054Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.00067Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.004406Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.02186Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.06973Least InformativeInherited
Worm Phenotype (WP)larval development variant0.8102Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00001206Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00001241Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0000245Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.001675Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.1048Moderately InformativeInherited
Worm Phenotype (WP)life span variant0.0002782InformativeDirect
Worm Phenotype (WP)locomotion reduced0.002818InformativeInherited
Worm Phenotype (WP)somatic cell death variant0.000000000003109Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.0000000006806Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0000000008456Highly InformativeDirect
Worm Phenotype (WP)muscle attachment variant0.00000008935Highly InformativeDirect
Worm Phenotype (WP)paralyzed0.00001953Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0001818Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lamin A/C globular tail domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Lamin A/C globular tail domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Internal database links ]