SUPERFAMILY 1.75 HMM library and genome assignments server

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Ngr ectodomain-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Family:   Ngr ectodomain-like [ 75142] (6)


Family statistics
Genomes (94) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 803 2,482 14
Proteins 802 2,479 14


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.01216Least InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.000000000001504InformativeDirect
Enzyme Commission (EC)Peroxidase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.05548Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1655Moderately InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.0003166InformativeDirect
Disease Ontology (DO)eye disease0.002218InformativeInherited
Disease Ontology (DO)myopia0.0000692Highly InformativeDirect
Disease Ontology (DO)corneal disease0.0008107Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.4861Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8354Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.8802Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9249Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.9619Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.9797Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.08214Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2695Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.4744Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.5579Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.5738Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.7146Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.7463Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.8846Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.9275Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.005409InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coagulation0.04275InformativeInherited
Phenotypic Abnormality (PA)Abnormal platelet count0.144InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.2291InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.2462InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.2951InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.3223InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.4781InformativeInherited
Phenotypic Abnormality (PA)Prolonged bleeding following procedure0.00004982Highly InformativeDirect
Phenotypic Abnormality (PA)Spontaneous hematomas0.00008058Highly InformativeDirect
Phenotypic Abnormality (PA)Menorrhagia0.0006488Highly InformativeDirect
Phenotypic Abnormality (PA)Hematuria0.003552Highly InformativeInherited
Phenotypic Abnormality (PA)Epistaxis0.006095Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1196Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.657Least InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.1843Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.2393Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2738Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.5498Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.6302Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6996Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.8738Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9821Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.01712InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.03834InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.06489InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.106InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.1139InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.1653InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.2827InformativeInherited
Mammalian Phenotype (MP)abnormal tendon morphology0.00001687Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.00001835Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.004816Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.006015Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.008701Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.02035Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.03297Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.05977Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.06272Least InformativeInherited
Fly Anatomy (FA)tagma0.1985Least InformativeInherited
Fly Anatomy (FA)segment0.248Least InformativeInherited
Fly Anatomy (FA)larva0.3722Least InformativeInherited
Fly Anatomy (FA)embryo0.5054Least InformativeInherited
Fly Anatomy (FA)nervous system0.6911Least InformativeInherited
Fly Anatomy (FA)larval tagma0.03122Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.1128Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval nervous system0.175Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1804Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.6173Moderately InformativeInherited
Fly Anatomy (FA)nerve0.01315InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.04383InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.1654InformativeInherited
Fly Anatomy (FA)intersegmental nerve0.001452Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.01013Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.2838InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.0002229Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.009053Least InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.000000000001307Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]