SUPERFAMILY 1.75 HMM library and genome assignments server

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Noncollagenous (NC1) domain of collagen IV family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   C-type lectin-like [ 56435]
Superfamily:   C-type lectin-like [ 56436] (8)
Family:   Noncollagenous (NC1) domain of collagen IV [ 75585]


Family statistics
Genomes (140) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,410 3,768 8
Proteins 737 1,991 4


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)syndrome0Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.000002507Moderately InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0000005921InformativeDirect
Disease Ontology (DO)kidney failure0.05805Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1723Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1788Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3018Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.01844Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.06836Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.1249Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1591Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.001268InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.001838InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.003159InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.006151InformativeInherited
Phenotypic Abnormality (PA)Increased inflammatory response1InformativeInherited
Phenotypic Abnormality (PA)Hematuria0.000001617Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal erosion0.000003471Highly InformativeDirect
Phenotypic Abnormality (PA)Nephritis0.00001954Highly InformativeDirect
Phenotypic Abnormality (PA)Myopia0.0001102Highly InformativeDirect
Phenotypic Abnormality (PA)Renal insufficiency0.000113Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.07876Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1495Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2575Least InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0007663Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0.004022Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.008188Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.01104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.02707Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.03878Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.00006465InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.0002218InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0003679InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.0004285InformativeDirect
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.0004605InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.2643InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus basement membrane morphology0.0000009999Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.000004526Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.000005522Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lens morphology0.000007873Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.00004033Highly InformativeDirect
Mammalian Phenotype (MP)decreased myeloid cell number0.0005838Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.003365Highly InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte cell number0.04324Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hematocrit0.0484Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney size0.09525Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)adipose tissue0Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 124 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a C-type lectin-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]