SUPERFAMILY 1.75 HMM library and genome assignments server

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Release factor superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Release factor [ 75619]
Superfamily:   Release factor [ 75620]
Families:   Release factor [ 75621] (2)


Superfamily statistics
Genomes (3,082) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,682 42,486 5
Proteins 7,653 42,431 5


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular nitrogen compound metabolic process0.00009430.0000001824Least InformativeDirect
Biological Process (BP)biosynthetic process0.0001420.000000478Least InformativeDirect
Biological Process (BP)single-organism cellular process0.18610.09503Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.0015820.0000139Least InformativeInherited
Biological Process (BP)primary metabolic process0.01770.001733Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0010980.0002322Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.00026280.002547Least InformativeInherited
Biological Process (BP)peptide metabolic process0.0000000000030230.00000000000007621Moderately InformativeDirect
Biological Process (BP)amide biosynthetic process0.000000000013410Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.0000000011990.000000000003751Moderately InformativeDirect
Biological Process (BP)gene expression0.0000000045250.00000000002466Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.00000067140.0000000432Moderately InformativeDirect
Biological Process (BP)cellular component disassembly0.00000000000016950Highly InformativeDirect
Molecular Function (MF)binding0.12940.1212Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.000000092770.00000006035Moderately InformativeDirect
Molecular Function (MF)RNA binding0.0000000013530.0000000000005061InformativeDirect
Molecular Function (MF)translation factor activity, RNA binding00.000000000002492Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.00051620.00000005357Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular nitrogen compound metabolic process 0.0000001824 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000478 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0002322 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0000139 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.09503 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.001733 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.002547 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0.00000000000007621 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.000000000003751 Moderately Informative Direct
Biological Process (BP) gene expression 0.00000000002466 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0000000432 Moderately Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Molecular Function (MF) binding 0.1212 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.00000006035 Moderately Informative Direct
Molecular Function (MF) RNA binding 0.0000000000005061 Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0.000000000002492 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000005357 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00003769 Least Informative Direct
Cellular Component (CC) plastid 0.00001307 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Release factor domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Release factor superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]