SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Cullin homology domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Cullin homology domain [ 75631]
Superfamily:   Cullin homology domain [ 75632]
Families:   Cullin homology domain [ 75633] (2)


Superfamily statistics
Genomes (505) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,623 8,618 4
Proteins 3,577 8,537 4


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.000000000000003734 Least Informative Direct
Biological Process (BP) biological regulation 0.000000255 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000451 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000007086 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.178 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1214 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 0.0000000000001047 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000000000113 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000003219 Moderately Informative Direct
Biological Process (BP) reproduction 0.00001543 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00003268 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000196 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.1268 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.8274 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.03486 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1669 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1947 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.4685 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05334 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.9105 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.2575 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3126 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1942 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.3292 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.317 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01178 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01691 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.2252 Moderately Informative Inherited
Biological Process (BP) cell communication 0.4529 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.0073 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) cell cycle process 0.0000000000003023 Informative Direct
Biological Process (BP) proteolysis 0.0000001175 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000009821 Informative Direct
Biological Process (BP) organelle localization 0.00008163 Informative Direct
Biological Process (BP) single organism reproductive process 0.00009366 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0005607 Informative Direct
Biological Process (BP) microtubule-based process 0.000604 Informative Direct
Biological Process (BP) generation of neurons 0.0006299 Informative Direct
Biological Process (BP) negative regulation of signaling 0.03077 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.3216 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1557 Informative Inherited
Biological Process (BP) intracellular transport 0.006386 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.2797 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.04275 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.007034 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.002261 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.002441 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6619 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.00828 Informative Inherited
Biological Process (BP) embryo development 0.001728 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.02354 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.07672 Informative Inherited
Biological Process (BP) cell death 0.001481 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.3578 Informative Inherited
Biological Process (BP) regulation of growth 0.00898 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.01826 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1669 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.05248 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.001189 Informative Inherited
Biological Process (BP) chromosome organization 0.0814 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0.00000000000001079 Highly Informative Direct
Biological Process (BP) regulation of chromosome segregation 0.00000000773 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0000002417 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0000004896 Highly Informative Direct
Biological Process (BP) nuclear division 0.0000006834 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.000001123 Highly Informative Direct
Biological Process (BP) apoptotic process 0.000003121 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000004352 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00001416 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.00002349 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00003127 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.00003403 Highly Informative Direct
Biological Process (BP) vesicle organization 0.00007406 Highly Informative Direct
Biological Process (BP) regulation of mitotic nuclear division 0.0001652 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.0003933 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.3238 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle 0.17 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.6267 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.02914 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.005272 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.4319 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.001215 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.008244 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.2264 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.0000009578 Least Informative Direct
Molecular Function (MF) binding 0.000002844 Least Informative Direct
Molecular Function (MF) enzyme binding 0.001552 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.1592 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3545 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.05087 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0004672 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.01333 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00000004782 Informative Direct
Cellular Component (CC) supramolecular polymer 0.001835 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.000000006703 Highly Informative Direct
Cellular Component (CC) spindle 0.000001767 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.8029Least InformativeInherited
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processCell cycle0.0000000001511Moderately InformativeDirect
Biological processHost-virus interaction0.0001703Moderately InformativeDirect
Biological processMitosis0.00004904InformativeDirect
Biological processER-Golgi transport0.00000000001801Highly InformativeDirect
Cellular componentNucleus0.000000005378Least InformativeDirect
Cellular componentCytoplasm0.799Least InformativeInherited
Cellular componentGolgi apparatus0.00000007123Moderately InformativeDirect
Cellular componentCytoskeleton0.0001938Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00006266Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin homology domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Cullin homology domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]