SUPERFAMILY 1.75 HMM library and genome assignments server

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Cullin homology domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Cullin homology domain [ 75631]
Superfamily:   Cullin homology domain [ 75632]
Families:   Cullin homology domain [ 75633] (2)


Superfamily statistics
Genomes (505) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,623 10,048 4
Proteins 3,577 9,967 4


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.02118Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.02625Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.2014Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.009945InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.05082InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.09019InformativeInherited
Mammalian Phenotype (MP)abnormal embryo size0.001122Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0.002573Highly InformativeInherited
Mammalian Phenotype (MP)abnormal preimplantation embryo morphology0.006891Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0001207Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001506Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.008785Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.00000003092Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0001226Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0003984Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0003996Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0006009Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0008859Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0009228Moderately InformativeDirect
Worm Phenotype (WP)non apoptotic cell death variant0.000000000007369InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00000000003703InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0.0000000002357InformativeDirect
Worm Phenotype (WP)life span variant0.00001265InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.000000000000214Highly InformativeDirect
Worm Phenotype (WP)apoptosis increased0.000000000001272Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.0000000001372Highly InformativeDirect
Worm Phenotype (WP)cell cycle progression variant0.0000005936Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.0000006942Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.0308Moderately InformativeInherited
Fly Anatomy (FA)epithelial cell0.00504InformativeInherited
Fly Anatomy (FA)ovariole0.008691InformativeInherited
Fly Anatomy (FA)germline cyst0.0136InformativeInherited
Fly Anatomy (FA)follicle cell0.0003896Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin homology domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Cullin homology domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]