SUPERFAMILY 1.75 HMM library and genome assignments server

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Extended AAA-ATPase domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Family:   Extended AAA-ATPase domain [ 81269] (28)


Family statistics
Genomes (3,262) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 69,729 444,459 60
Proteins 59,159 380,602 56


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)DNA-directed DNA polymerase0.0000000001761InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.00123Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.002522Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.03684Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.05106Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.07605Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1632Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.583Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.888Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.000405Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0.00566Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.009766Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.01986Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.1604Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.1877Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1882Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.4802Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.5123Moderately InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.0004468InformativeDirect
Phenotypic Abnormality (PA)Hypertonia0.03075InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.1147InformativeInherited
Phenotypic Abnormality (PA)Abnormal involuntary eye movements0.1231InformativeInherited
Phenotypic Abnormality (PA)Nystagmus0.0002444Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the stomach0.0009234Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of female external genitalia0.004262Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coordination0.05952Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.005736Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1321Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.0001696InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000001071Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0001424Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.02688Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04882Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.07813Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000000000005521Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.00000002794Moderately InformativeDirect
Worm Phenotype (WP)cell cycle variant0.000000145Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.0000002361Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.001172Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.0968Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.2968Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.7517Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.0000005719InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0000006148InformativeDirect
Worm Phenotype (WP)sick0.0004793InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.1056InformativeInherited
Worm Phenotype (WP)nuclear positioning variant0.2093InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.2095InformativeInherited
Worm Phenotype (WP)multiple nuclei0.0000000001701Highly InformativeDirect
Worm Phenotype (WP)endoplasmic reticulum morphology variant0.000008484Highly InformativeDirect
Worm Phenotype (WP)embryonic cell morphology variant0.00001769Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00002336Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.0007304Highly InformativeDirect
Worm Phenotype (WP)meiosis defective early emb0.0008845Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.007045Highly InformativeInherited
Worm Phenotype (WP)nucleus defective early emb0.007849Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.02084Highly InformativeInherited
Worm Phenotype (WP)germ cell compartment size variant0.4565Highly InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb0.4925Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.01794Least InformativeInherited
Fly Anatomy (FA)late embryo0.1844Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval fat body0.0009325Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0.002092Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.02401Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.08539Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.0001713Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.1306Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ATP; involved in cellular and subcellular movement0InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0.0000000002377InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited

Document: EC annotation of SCOP domains

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Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 512 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a P-loop containing nucleoside triphosphate hydrolases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]