SUPERFAMILY 1.75 HMM library and genome assignments server

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Extended AAA-ATPase domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Family:   Extended AAA-ATPase domain [ 81269] (28)


Family statistics
Genomes (3,262) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 69,729 444,459 60
Proteins 59,159 380,602 56


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)DNA-directed DNA polymerase0.0000000001761InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.001226Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.002533Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.03696Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.05113Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.07625Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1629Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.5836Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.8882Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.0004032Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0.005687Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.009813Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.01985Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.1612Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.1883Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1887Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.4811Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.5124Moderately InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.0004456InformativeDirect
Phenotypic Abnormality (PA)Hypertonia0.03078InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.1154InformativeInherited
Phenotypic Abnormality (PA)Abnormal involuntary eye movements0.1232InformativeInherited
Phenotypic Abnormality (PA)Nystagmus0.0002438Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the stomach0.0009221Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of female external genitalia0.004263Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coordination0.05911Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.005727Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1322Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.0001695InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000001082Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0001444Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0273Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04952Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.07909Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000000000005676Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.00000002806Moderately InformativeDirect
Worm Phenotype (WP)cell cycle variant0.0000001427Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.0000002346Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.001159Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.097Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.2964Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.75Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.0000005794InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0000006236InformativeDirect
Worm Phenotype (WP)sick0.0004758InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.1069InformativeInherited
Worm Phenotype (WP)nuclear positioning variant0.207InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.2094InformativeInherited
Worm Phenotype (WP)multiple nuclei0.0000000001727Highly InformativeDirect
Worm Phenotype (WP)endoplasmic reticulum morphology variant0.000008516Highly InformativeDirect
Worm Phenotype (WP)embryonic cell morphology variant0.0000178Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00002203Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.000734Highly InformativeDirect
Worm Phenotype (WP)meiosis defective early emb0.0008909Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.007045Highly InformativeInherited
Worm Phenotype (WP)nucleus defective early emb0.007849Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.02088Highly InformativeInherited
Worm Phenotype (WP)germ cell compartment size variant0.4517Highly InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb0.4925Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0.00208Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.024Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.08535Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.0001713Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.1306Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ATP; involved in cellular and subcellular movement0InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0.0000000002377InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited

Document: EC annotation of SCOP domains

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Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 512 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a P-loop containing nucleoside triphosphate hydrolases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]