SUPERFAMILY 1.75 HMM library and genome assignments server

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NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Family:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)


Family statistics
Genomes (130) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 947 2,684 38
Proteins 947 2,684 38


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.04468Least InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.04262Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.06045Moderately InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.02601InformativeInherited
Disease Ontology (DO)large intestine cancer0.1032InformativeInherited
Disease Ontology (DO)hemangioma0.00004836Highly InformativeDirect
Disease Ontology (DO)colon cancer0.0009581Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.08626Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.481Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.001527Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.1067Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1379Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.01401InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair quantity0.01612InformativeInherited
Phenotypic Abnormality (PA)Leukopenia0.0006066Highly InformativeDirect
Phenotypic Abnormality (PA)Alopecia0.0006886Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.001804Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.001978Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.003049Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.004487Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007064Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.01125Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.09716Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000006433Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal B cell morphology0.0000002568Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0.000005742Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.000006737Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0000143Moderately InformativeDirect
Mammalian Phenotype (MP)increased hematopoietic cell number0.00004408Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.00004771Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0.00006104Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0001094Moderately InformativeDirect
Mammalian Phenotype (MP)decreased hematopoietic cell number0.000188Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.0002121Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.0003329Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0.0007314Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.002131Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.005091Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.008117Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.009758Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01561Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.01621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.01736Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.02133Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.05995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.07855Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1187Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2485Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2676Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.3756Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.3808Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.5512Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.6447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.000000009818InformativeDirect
Mammalian Phenotype (MP)abnormal immunoglobulin level0.00000002898InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0000001861InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0000003304InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.00005206InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.00007404InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.0001531InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0004006InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.0004755InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.0005644InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.001947InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.00286InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.005744InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.00801InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.009771InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.01222InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.0158InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.02458InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.1019InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.2339InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.5685InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.5818InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.6415InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.000000008356Highly InformativeDirect
Mammalian Phenotype (MP)lung inflammation0.00000002623Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trigeminal nerve morphology0.0000003842Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell proliferation0.0000006519Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.00002582Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.00002685Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.00003094Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00004644Highly InformativeDirect
Mammalian Phenotype (MP)increased IgG2a level0.00008386Highly InformativeDirect
Mammalian Phenotype (MP)abnormal dorsal aorta morphology0.0002839Highly InformativeDirect
Mammalian Phenotype (MP)abnormal IgG2b level0.0003318Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.0005596Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD8-positive, alpha-beta T cell number0.000629Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD4-positive, alpha beta T cell number0.0009236Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.001411Highly InformativeInherited
Mammalian Phenotype (MP)increased bone mass0.001891Highly InformativeInherited
Mammalian Phenotype (MP)abnormal placenta labyrinth morphology0.001993Highly InformativeInherited
Mammalian Phenotype (MP)abnormal anxiety-related response0.01014Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle tissue morphology0.02455Highly InformativeInherited
Mammalian Phenotype (MP)abnormal large intestine morphology0.04985Highly InformativeInherited
Mammalian Phenotype (MP)decreased IgG level0.1624Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)immune response defective0.0009287InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)nervous system0.08479Least InformativeInherited
Fly Anatomy (FA)segment0.3453Least InformativeInherited
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)digestive system0.0004521Moderately InformativeDirect
Fly Anatomy (FA)adult external thorax0.006328Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.006956Moderately InformativeInherited
Fly Anatomy (FA)circulatory system0.02821Moderately InformativeInherited
Fly Anatomy (FA)neuron0.04595Moderately InformativeInherited
Fly Anatomy (FA)anatomical space0.004046InformativeInherited
Fly Anatomy (FA)mechanosensory system0.02077InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.05342InformativeInherited
Fly Anatomy (FA)chaeta0.7151InformativeInherited
Fly Anatomy (FA)mesothoracic tergum0.000001047Highly InformativeDirect
Fly Anatomy (FA)macrochaeta0.00005807Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0002489Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval motor neuron0.0003566Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 164 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]