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Nucleotidyltransferase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Nucleotidyltransferase [ 81302]
Superfamily:   Nucleotidyltransferase [ 81301] (14)
Families:   Catalytic subunit of bi-partite nucleotidyltransferase [ 102932] (3)
  Kanamycin nucleotidyltransferase (KNTase), N-terminal domain [ 56708]
  Poly(A) polymerase, PAP, N-terminal domain [ 81589]
  2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain [ 102937]
  Archaeal tRNA CCA-adding enzyme catalytic domain [ 102940]
  DNA polymerase beta-like [ 81300] (4)
  Poly A polymerase head domain-like [ 82661] (2)
  RelA/SpoT domain [ 102945] (2)
  GlnE-like domain [ 110933]
  RNA editing terminal uridyl transferase 2, RET2, catalytic domain [ 143236]
  TM1012-like [ 143239]
  Iojap/YbeB-like [ 160252] (2)
  AadK N-terminal domain-like [ 160257]
  GrpB-like [ 160260]


Superfamily statistics
Genomes (3,207) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 29,224 207,138 42
Proteins 27,711 195,711 42


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0.0000002083InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)CCA tRNA nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0.00000000005709Highly InformativeDirect
Enzyme Commission (EC)DNA nucleotidylexotransferase0.000000002012Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.3867Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5598Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.09534Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.1442Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2464Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.002384InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin V(D)J recombination0.00000001729Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0004055Least InformativeDirect
Worm Phenotype (WP)RNA expression variant0.000000002372InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.0004957InformativeDirect
Worm Phenotype (WP)miRNA expression variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.5133Least InformativeInherited
Yeast Phenotype (YP)RNA accumulation0.0001577Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.4809Least InformativeInherited
Plant ANatomical entity (PAN)radicle0.0000003898Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0Highly InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0.000000000000005881Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleotidyltransferase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the Nucleotidyltransferase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]