SUPERFAMILY 1.75 HMM library and genome assignments server

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DEATH domain, DD family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Family:   DEATH domain, DD [ 81312] (8)


Family statistics
Genomes (81) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 522 1,398 10
Proteins 522 1,398 10


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.1477Moderately InformativeInherited
Disease Ontology (DO)gastritis0.0007332Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.002435Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07436Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1375Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.194Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2029Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7257Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.0002572Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.001724Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.004167Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.006967Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.01764Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.09247Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1176Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.4259Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.00002237InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0.0007232InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.006413InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.02768InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.03056InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.04484InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.06141InformativeInherited
Phenotypic Abnormality (PA)Vasculitis0.00009477Highly InformativeDirect
Phenotypic Abnormality (PA)Uveitis0.0005803Highly InformativeDirect
Phenotypic Abnormality (PA)Hematological neoplasm0.007784Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0001007Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.01374Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.01667Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.02005Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.3358Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7352Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.00002082Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.0001682Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.0007531Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.002497Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.00673Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.012Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.021Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.04537Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.0715Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.08146Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.1265Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1614Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2173Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.2319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.2439Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.2828Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.5656Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.6392Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.000002928InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0004542InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.0006735InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.01397InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.01537InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.02502InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.03038InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.03926InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.0469InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.07916InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.1449InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.2768InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.8926InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0000005247Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00001809Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.00005536Highly InformativeDirect
Mammalian Phenotype (MP)abnormal IgG2b level0.0003618Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0005722Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tooth morphology0.0006051Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.0007515Highly InformativeDirect
Mammalian Phenotype (MP)increased IgG2a level0.000987Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage B cell morphology0.001288Highly InformativeInherited
Mammalian Phenotype (MP)increased immature B cell number0.01865Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.00133Moderately InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.00002246InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]