SUPERFAMILY 1.75 HMM library and genome assignments server

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T-box family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Family:   T-box [ 81316] (2)


Family statistics
Genomes (149) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,006 5,179 2
Proteins 2,003 5,158 2


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)physical disorder0.00003327InformativeDirect
Disease Ontology (DO)heart disease0.0302InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2581Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2879Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.5421Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.1884Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.2691Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.4803Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.0008143InformativeDirect
Phenotypic Abnormality (PA)Abnormal palate morphology0.02324InformativeInherited
Phenotypic Abnormality (PA)Atrial septal defect0.0003472Highly InformativeDirect
Phenotypic Abnormality (PA)Cleft palate0.0007288Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.001955Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.00289Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01166Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3479Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.0003392Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0007526Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0.0007703Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0.001415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.02478Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.09564Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.1325Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.00006927InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.00258InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.03125InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.03707InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.04332InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.164InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.2731InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.2817InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.3227InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.000000643Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate morphology0.00001975Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00005173Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.00007596Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0001474Highly InformativeDirect
Mammalian Phenotype (MP)abnormal occipital bone morphology0.0002821Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.0003938Highly InformativeDirect
Mammalian Phenotype (MP)embryonic lethality during organogenesis, complete penetrance0.0005296Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart atrium morphology0.03406Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical vertebrae morphology0.07137Highly InformativeInherited
Mammalian Phenotype (MP)abnormal rib morphology0.6931Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.2384Least InformativeInherited
Fly Anatomy (FA)late embryo0.2041Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.01486InformativeInherited
Fly Anatomy (FA)embryonic/larval dorsal vessel0.00009837Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.02351Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.03705Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2335Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.3591Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.001503Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.0202Moderately InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.0002803InformativeDirect
Zebrafish Anatomy (ZA)embryonic structure0.0008511InformativeDirect
Zebrafish Anatomy (ZA)pericardial region0.03576InformativeInherited
Zebrafish Anatomy (ZA)heart primordium0.0002589Highly InformativeDirect
Zebrafish Anatomy (ZA)heart0.001363Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.02843Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.04791Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1513Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.3242Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.6612Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.6896Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.000241Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0004229Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0008037Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.02152Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8822Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8979Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.9826Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.00000236InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00002368InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00002764InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00003518InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0000555InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0005203InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.005927InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.017InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.4761InformativeInherited
Xenopus ANatomical entity (XAN)limb0.479InformativeInherited
Xenopus ANatomical entity (XAN)foregut0.00001738Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00002539Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.00006618Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.000135Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.000276Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.009779Highly InformativeInherited
Xenopus ANatomical entity (XAN)blastopore lip0.7942Highly InformativeInherited
Xenopus ANatomical entity (XAN)pelvic appendage0.9506Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.7347Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.0007417Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]