SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Rhodopsin-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Family:   Rhodopsin-like [ 81320]


Family statistics
Genomes (129) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,106 20,933 1
Proteins 2,097 20,916 1


Disease Ontology (DO)

(
show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.6342Least InformativeInherited
Disease Ontology (DO)disease of mental health0.000003277Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.000181Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.003818Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.02022Moderately InformativeInherited
Disease Ontology (DO)asthma0.0000008066InformativeDirect
Disease Ontology (DO)overnutrition0.000008307InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.1109InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.3741InformativeInherited
Disease Ontology (DO)migraine0.000005391Highly InformativeDirect
Disease Ontology (DO)anxiety disorder0.0002661Highly InformativeDirect
Disease Ontology (DO)endocrine organ benign neoplasm0.00477Highly InformativeInherited
Disease Ontology (DO)specific developmental disorder0.083Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.8108Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.03915Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.06169Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.4564Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.7646Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.9723Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.9852Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.01867InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.194InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.4567InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.4961InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.7893InformativeInherited
Phenotypic Abnormality (PA)Color vision defect0.001483Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal ovarian morphology0.01597Highly InformativeInherited
Phenotypic Abnormality (PA)Joint laxity0.1428Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the penis0.2529Highly InformativeInherited
Phenotypic Abnormality (PA)Sensorineural hearing impairment0.4169Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.002932Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01297Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.07193Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1064Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4486Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.6546Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9505Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.0000008942Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.000005772Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.00003629Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.04503Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.05981Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.09482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1068Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1999Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.2456Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.6362Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.6401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9318Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.9504Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.9733Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9962Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.9979Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.0000001771InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.000003236InformativeDirect
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.00005906InformativeDirect
Mammalian Phenotype (MP)abnormal consumption behavior0.00006239InformativeDirect
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.0006895InformativeDirect
Mammalian Phenotype (MP)abnormal cell migration0.002224InformativeInherited
Mammalian Phenotype (MP)abnormal sensory capabilities/reflexes/nociception0.09215InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.1747InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.2396InformativeInherited
Mammalian Phenotype (MP)seizures0.4725InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.5753InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.5802InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.7092InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.7389InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8744InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.914InformativeInherited
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.000002168Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00000785Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.000009979Highly InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.00003337Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.00005109Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gallbladder physiology0.0002222Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.0003895Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0004151Highly InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to pharmacologically induced seizures0.0005534Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.0006634Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.004104Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.06643Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.3866Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.4739Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diencephalon morphology0.5252Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neuroendocrine gland morphology0.6685Highly InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.8651Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.03334Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.9182Least InformativeInherited
Worm Phenotype (WP)movement variant0.00000004409Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.0695Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.1717Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.1766Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.9496Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0InformativeDirect
Worm Phenotype (WP)head movement variant0.00000000000001249InformativeDirect
Worm Phenotype (WP)body posture variant0.00000000006363InformativeDirect
Worm Phenotype (WP)tail bend angle variant0.0000000004517InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.00000002171InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0000004363InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.000001023InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.000168InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0002015InformativeDirect
Worm Phenotype (WP)drug resistant0.007788InformativeInherited
Worm Phenotype (WP)chemical resistant0.07114InformativeInherited
Worm Phenotype (WP)chemosensory response variant0.1369InformativeInherited
Worm Phenotype (WP)drug hypersensitive0.8305InformativeInherited
Worm Phenotype (WP)locomotion reduced0.8762InformativeInherited
Worm Phenotype (WP)chemical hypersensitive1InformativeInherited
Worm Phenotype (WP)coiling frequency variant0.000000002528Highly InformativeDirect
Worm Phenotype (WP)serotonin response variant0.000000006636Highly InformativeDirect
Worm Phenotype (WP)egg laying response to drug variant0.000001011Highly InformativeDirect
Worm Phenotype (WP)fat0.000038Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.000284Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.00207Highly InformativeInherited
Worm Phenotype (WP)pharyngeal pumping rate variant0.03205Highly InformativeInherited
Worm Phenotype (WP)egg laying defective1Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0000001745InformativeDirect
Fly Phenotype (FP)hypoactive0.00000000009984Highly InformativeDirect
Fly Phenotype (FP)courtship behavior defective0.00001349Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.9337Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system1InformativeInherited
Xenopus ANatomical entity (XAN)eye1InformativeInherited
Xenopus ANatomical entity (XAN)surface structure1InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.2611Highly InformativeInherited
Xenopus ANatomical entity (XAN)olfactory system0.7294Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage1Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.00001731Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Family A G protein-coupled receptor-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]