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Family A G protein-coupled receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Families:   Bacteriorhodopsin-like [ 81319] (5)
  Rhodopsin-like [ 81320]


Superfamily statistics
Genomes (556) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 79,708 220,865 43
Proteins 78,352 217,479 43


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5999Least InformativeInherited
Disease Ontology (DO)disease of mental health0.0000009865Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0001812Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.006128Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.03056Moderately InformativeInherited
Disease Ontology (DO)brain disease0.07195Moderately InformativeInherited
Disease Ontology (DO)asthma0.0000003616InformativeDirect
Disease Ontology (DO)overnutrition0.000005413InformativeDirect
Disease Ontology (DO)migraine0.00002326InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2291InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.3292InformativeInherited
Disease Ontology (DO)anxiety disorder0.000008485Highly InformativeDirect
Disease Ontology (DO)eating disorder0.0000184Highly InformativeDirect
Disease Ontology (DO)endocrine organ benign neoplasm0.002836Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.8363Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.05646Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.3792Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.504Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.975Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.3511InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0.5804InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.8457InformativeInherited
Phenotypic Abnormality (PA)Decreased body weight0.9948InformativeInherited
Phenotypic Abnormality (PA)Color vision defect0.003411Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the penis0.32Highly InformativeInherited
Phenotypic Abnormality (PA)Sensorineural hearing impairment0.5588Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.006284Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.02978Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.05632Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.05993Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4581Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9886Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.00000005611Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.000009446Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.05569Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.05666Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.06806Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.08588Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1099Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.2114Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2686Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.34Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5721Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7243Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.729Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.8104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.9545Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9585Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.000000005622InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000002794InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.000009888InformativeDirect
Mammalian Phenotype (MP)abnormal consumption behavior0.00001291InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.00006707InformativeDirect
Mammalian Phenotype (MP)increased body weight0.00006842InformativeDirect
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.0001461InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0004006InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0.003104InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.01032InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.056InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.2061InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2423InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.5147InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.5906InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.6513InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.8406InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8454InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.945InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9801InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.000001496Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.000009705Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.00001318Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.00002196Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0000231Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gallbladder physiology0.0001398Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0002494Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.0002558Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.0004114Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.0004389Highly InformativeDirect
Mammalian Phenotype (MP)abnormal locomotor activation0.0007118Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0007843Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.0007893Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.002887Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgE level0.003211Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.08449Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nose morphology0.1251Highly InformativeInherited
Mammalian Phenotype (MP)decreased immunoglobulin level0.2459Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.399Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)drug response variant1Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant1Moderately InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)serotonin resistant0.03514Highly InformativeInherited
Worm Phenotype (WP)serotonin response variant0.03997Highly InformativeInherited
Worm Phenotype (WP)pharyngeal pumping rate variant0.1498Highly InformativeInherited
Worm Phenotype (WP)pharyngeal pumping irregular0.3459Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.000001109Moderately InformativeDirect
Fly Phenotype (FP)hypoactive0.000000000002513Highly InformativeDirect
Fly Phenotype (FP)mating defective0.00004788Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.6373Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.1283InformativeInherited
Xenopus ANatomical entity (XAN)dermal system1InformativeInherited
Xenopus ANatomical entity (XAN)surface structure1InformativeInherited
Xenopus ANatomical entity (XAN)neural nucleus0.000001613Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.8149Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0000007791Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Family A G protein-coupled receptor-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Family A G protein-coupled receptor-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]