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Voltage-gated potassium channels superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Voltage-gated potassium channels [ 81325]
Superfamily:   Voltage-gated potassium channels [ 81324]
Families:   Voltage-gated potassium channels [ 81323] (5)


Superfamily statistics
Genomes (2,257) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 39,381 135,221 19
Proteins 26,941 98,698 19


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.000135Least InformativeDirect
Disease Ontology (DO)cardiovascular system disease0.5144Least InformativeInherited
Disease Ontology (DO)disease of mental health0.00000191Moderately InformativeDirect
Disease Ontology (DO)brain disease0.00002907Moderately InformativeDirect
Disease Ontology (DO)syndrome0.02287Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.7445Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.000007805InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.0001636InformativeDirect
Disease Ontology (DO)peripheral nervous system disease0.5007InformativeInherited
Disease Ontology (DO)focal epilepsy0.6792InformativeInherited
Disease Ontology (DO)temporal lobe epilepsy0.00001512Highly InformativeDirect
Disease Ontology (DO)metal metabolism disorder0.003499Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00000005067Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.07763Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2594Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3316Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.4408Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6286Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.9399Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9938Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.004866Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.101Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1132Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1641Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.1841Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.3306Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye morphology0.6536Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.8229Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.8423Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.9816Moderately InformativeInherited
Phenotypic Abnormality (PA)Epileptic encephalopathy0.0000000009672InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.0000917InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cation homeostasis0.0252InformativeInherited
Phenotypic Abnormality (PA)Seizures0.03023InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.03259InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.2333InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.4624InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.6375InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac test0.00000002665Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.000002408Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.000004544Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.000005155Highly InformativeDirect
Phenotypic Abnormality (PA)Involuntary movements0.00003171Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0000993Highly InformativeDirect
Phenotypic Abnormality (PA)Metabolic alkalosis0.0000993Highly InformativeDirect
Phenotypic Abnormality (PA)EEG abnormality0.0001634Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0001917Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0001917Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.00144Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.0115Highly InformativeInherited
Phenotypic Abnormality (PA)Paralysis0.2712Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.000039Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2052Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.00000006425Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0.001627Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.007678Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2926Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.3494Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.6872Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.000000335InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000001787InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.00003048InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.00006655InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.02144InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.03719InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.0819InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2694InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.8561InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission1InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.0000000000000174Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00000003199Highly InformativeDirect
Mammalian Phenotype (MP)muscle twitch0.00003461Highly InformativeDirect
Mammalian Phenotype (MP)decreased alcohol consumption0.0007687Highly InformativeDirect
Mammalian Phenotype (MP)abnormal exploration in a new environment0.000799Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.005951Highly InformativeInherited
Mammalian Phenotype (MP)abnormal breathing pattern0.04113Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.1089Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.7577Highly InformativeInherited
Mammalian Phenotype (MP)abnormal reflex0.8388Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.001522Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.03909Least InformativeInherited
Worm Phenotype (WP)cell development variant0.4537Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.8575Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.9172Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.9475Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.0003126Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.008508Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.06325Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1005Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.1674Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.5895Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.9255Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.0000000009859InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000000758InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.000001057InformativeDirect
Worm Phenotype (WP)growth rate variant0.000002279InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.00001116InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00002311InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0000528InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.00005507InformativeDirect
Worm Phenotype (WP)localized movement variant0.0001868InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0002462InformativeDirect
Worm Phenotype (WP)body posture variant0.0005436InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0007772InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.001737InformativeInherited
Worm Phenotype (WP)body length variant0.01112InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.04562InformativeInherited
Worm Phenotype (WP)defecation variant0.08789InformativeInherited
Worm Phenotype (WP)egg laying variant0.1257InformativeInherited
Worm Phenotype (WP)body width variant0.2723InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.2842InformativeInherited
Worm Phenotype (WP)coiling frequency0.000002427Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000002602Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.000006385Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.000008296Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.00001953Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0002323Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0006831Highly InformativeDirect
Worm Phenotype (WP)serotonin response variant0.0007986Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.001473Highly InformativeInherited
Worm Phenotype (WP)egg retention0.2993Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.00009176InformativeDirect
Fly Phenotype (FP)sensory perception defective0.0009804InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.0009916InformativeDirect
Fly Phenotype (FP)chemical resistant0.0009465Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1451Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.2869Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4655Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.08635Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.336Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0002406InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.01505InformativeInherited
Xenopus ANatomical entity (XAN)eye0.6228InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.00005738Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal outer plexiform layer0.0001969Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0002962Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0007372Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0000002799Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)early tailbud stage0.0414Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Voltage-gated potassium channels domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Voltage-gated potassium channels superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]