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Voltage-gated potassium channels superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Voltage-gated potassium channels [ 81325]
Superfamily:   Voltage-gated potassium channels [ 81324]
Families:   Voltage-gated potassium channels [ 81323] (5)


Superfamily statistics
Genomes (2,257) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 39,381 135,221 19
Proteins 26,941 98,698 19


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0001335Least InformativeDirect
Disease Ontology (DO)disease of mental health0.000001921Moderately InformativeDirect
Disease Ontology (DO)brain disease0.00002964Moderately InformativeDirect
Disease Ontology (DO)syndrome0.02291Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.745Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.000007842InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.0001547InformativeDirect
Disease Ontology (DO)peripheral nervous system disease0.5014InformativeInherited
Disease Ontology (DO)focal epilepsy0.6793InformativeInherited
Disease Ontology (DO)temporal lobe epilepsy0.00001515Highly InformativeDirect
Disease Ontology (DO)metal metabolism disorder0.003508Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00000002453Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.004201Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.02814Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1755Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5811Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.6729Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.6887Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.9479Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9553Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.03345Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1781Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1799Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.2238Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.3234Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.3545Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.3712Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.8303Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.8651Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.9363Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.9873Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb1Moderately InformativeInherited
Phenotypic Abnormality (PA)Encephalopathy0.00002445InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.00009517InformativeDirect
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.0001022InformativeDirect
Phenotypic Abnormality (PA)Involuntary movements0.0002482InformativeDirect
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.001797InformativeInherited
Phenotypic Abnormality (PA)Seizures0.003963InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.01278InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.1894InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.4531InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.6719InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.7433InformativeInherited
Phenotypic Abnormality (PA)Epileptic encephalopathy0.000000000003712Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.00000000002058Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.000000005848Highly InformativeDirect
Phenotypic Abnormality (PA)Arrhythmia0.00003311Highly InformativeDirect
Phenotypic Abnormality (PA)Metabolic alkalosis0.00009133Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0001768Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0001768Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.000234Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal autonomic nervous system physiology0.0004117Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ankles0.06682Highly InformativeInherited
Phenotypic Abnormality (PA)Paralysis0.2928Highly InformativeInherited
Phenotypic Abnormality (PA)Sensory impairment0.4504Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00003911Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2034Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.00000006207Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0.001637Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.007614Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2936Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.3485Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.6884Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.0000003361InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000001792InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.00003048InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.00006589InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.02109InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.03756InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.082InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2695InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.8563InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission1InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.00000000000001742Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00000003181Highly InformativeDirect
Mammalian Phenotype (MP)muscle twitch0.00003421Highly InformativeDirect
Mammalian Phenotype (MP)decreased alcohol consumption0.0007666Highly InformativeDirect
Mammalian Phenotype (MP)abnormal exploration in a new environment0.0007937Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.005937Highly InformativeInherited
Mammalian Phenotype (MP)abnormal breathing pattern0.04099Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.1089Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.7577Highly InformativeInherited
Mammalian Phenotype (MP)abnormal reflex0.8362Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.06923Least InformativeInherited
Worm Phenotype (WP)cell development variant0.465Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.8796Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.9178Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.9635Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.9903Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)movement variant0.0003047Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.02167Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.03924Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.04042Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.09707Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.3015Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4338Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.4879Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.000000001162InformativeDirect
Worm Phenotype (WP)body bend variant0.00005157InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00007239InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00008862InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001549InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0002719InformativeDirect
Worm Phenotype (WP)body posture variant0.0002954InformativeDirect
Worm Phenotype (WP)localized movement variant0.0007025InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.001919InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.004877InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.00863InformativeInherited
Worm Phenotype (WP)male mating variant0.0163InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.02248InformativeInherited
Worm Phenotype (WP)egg laying variant0.03127InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.04772InformativeInherited
Worm Phenotype (WP)defecation variant0.06396InformativeInherited
Worm Phenotype (WP)drug resistant0.112InformativeInherited
Worm Phenotype (WP)directionality variant0.173InformativeInherited
Worm Phenotype (WP)small0.2708InformativeInherited
Worm Phenotype (WP)protein degradation variant0.0000001038Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.000003177Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.000003251Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000004523Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.000007784Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.00001062Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.00001818Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001009Highly InformativeDirect
Worm Phenotype (WP)short0.0002888Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.0003812Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0007253Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.003127Highly InformativeInherited
Worm Phenotype (WP)post hermaphrodite contact variant0.04134Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.5327Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0002072Moderately InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.0001158InformativeDirect
Fly Phenotype (FP)chemical resistant0.0009477Highly InformativeDirect
Fly Phenotype (FP)chemical sensitive0.0009815Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1633Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.2883Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4886Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1066Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.2699Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0002585InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.02267InformativeInherited
Xenopus ANatomical entity (XAN)eye0.5142InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.0001307Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal neural layer0.0004308Highly InformativeDirect
Xenopus ANatomical entity (XAN)cell part0.0004533Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0000001819Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Voltage-gated potassium channels domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Voltage-gated potassium channels superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]