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Voltage-gated potassium channels superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Voltage-gated potassium channels [ 81325]
Superfamily:   Voltage-gated potassium channels [ 81324]
Families:   Voltage-gated potassium channels [ 81323] (5)


Superfamily statistics
Genomes (2,257) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 39,381 135,221 19
Proteins 26,941 98,698 19


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0001335Least InformativeDirect
Disease Ontology (DO)disease of mental health0.000001921Moderately InformativeDirect
Disease Ontology (DO)brain disease0.00002964Moderately InformativeDirect
Disease Ontology (DO)syndrome0.02291Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.745Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.000007842InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.0001547InformativeDirect
Disease Ontology (DO)peripheral nervous system disease0.5014InformativeInherited
Disease Ontology (DO)focal epilepsy0.6793InformativeInherited
Disease Ontology (DO)temporal lobe epilepsy0.00001515Highly InformativeDirect
Disease Ontology (DO)metal metabolism disorder0.003508Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00000001811Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.005064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.03729Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.57Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7449Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.8337Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.949Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9752Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1383Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.2073Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.2847Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.3593Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.3945Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.7812Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.8703Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.979Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb1Moderately InformativeInherited
Phenotypic Abnormality (PA)Encephalopathy0.00004982InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.00005388InformativeDirect
Phenotypic Abnormality (PA)Involuntary movements0.0001218InformativeDirect
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.0002709InformativeDirect
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.002316InformativeInherited
Phenotypic Abnormality (PA)Seizures0.005781InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.01553InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.5399InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.5975InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.9208InformativeInherited
Phenotypic Abnormality (PA)Abnormal atrioventricular conduction0.00000000003506Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.0000000001874Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.000000002604Highly InformativeDirect
Phenotypic Abnormality (PA)Arrhythmia0.00001974Highly InformativeDirect
Phenotypic Abnormality (PA)Metabolic alkalosis0.00008184Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0001599Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0001599Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0002132Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal autonomic nervous system physiology0.0003846Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.002205Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ankles0.1368Highly InformativeInherited
Phenotypic Abnormality (PA)Paralysis0.2533Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00003863Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2034Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.00000006323Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0.001637Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.007614Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2935Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.3485Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.6884Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.0000003363InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000001791InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.00003048InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.0000659InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.02109InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.03755InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.08198InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2695InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.8563InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission1InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.00000000000001742Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00000003181Highly InformativeDirect
Mammalian Phenotype (MP)muscle twitch0.00003421Highly InformativeDirect
Mammalian Phenotype (MP)decreased alcohol consumption0.0007666Highly InformativeDirect
Mammalian Phenotype (MP)abnormal exploration in a new environment0.0007937Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.005938Highly InformativeInherited
Mammalian Phenotype (MP)abnormal breathing pattern0.04099Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.1089Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.7577Highly InformativeInherited
Mammalian Phenotype (MP)abnormal reflex0.8363Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.005601Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.04682Least InformativeInherited
Worm Phenotype (WP)cell development variant0.4898Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.8574Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.9518Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.9571Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.9979Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)movement variant0.0004043Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.003581Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.1042Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1785Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.1844Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.2468Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.2468Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.2477Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.2486Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.3649Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.5066Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.0000000009952InformativeDirect
Worm Phenotype (WP)body bend variant0.00003983InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.00005154InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00006162InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00008796InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0002453InformativeDirect
Worm Phenotype (WP)body posture variant0.0003305InformativeDirect
Worm Phenotype (WP)localized movement variant0.0006857InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0007418InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.001707InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.00273InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.00523InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.01935InformativeInherited
Worm Phenotype (WP)egg laying variant0.03376InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.04886InformativeInherited
Worm Phenotype (WP)defecation variant0.07235InformativeInherited
Worm Phenotype (WP)drug resistant0.1118InformativeInherited
Worm Phenotype (WP)directionality variant0.1808InformativeInherited
Worm Phenotype (WP)small0.2739InformativeInherited
Worm Phenotype (WP)protein degradation variant0.00000009176Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.000002701Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.000002807Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.00000367Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.000007363Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.00000956Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.00002029Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001104Highly InformativeDirect
Worm Phenotype (WP)short0.0002718Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.0003694Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0006615Highly InformativeDirect
Worm Phenotype (WP)serotonin response variant0.0007918Highly InformativeDirect
Worm Phenotype (WP)serotonin resistant0.0009592Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.003112Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0001589Moderately InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.0001032InformativeDirect
Fly Phenotype (FP)chemical resistant0.0009378Highly InformativeDirect
Fly Phenotype (FP)chemical sensitive0.000941Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.289Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.488Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.09953Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.303Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0002528InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.02199InformativeInherited
Xenopus ANatomical entity (XAN)eye0.5181InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.00008456Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0001066Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0001344Highly InformativeDirect
Xenopus ANatomical entity (XAN)cell part0.0004085Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0000001823Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Voltage-gated potassium channels domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Voltage-gated potassium channels superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]