SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Voltage-gated potassium channels superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Voltage-gated potassium channels [ 81325]
Superfamily:   Voltage-gated potassium channels [ 81324]
Families:   Voltage-gated potassium channels [ 81323] (5)


Superfamily statistics
Genomes (2,257) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 39,381 135,221 19
Proteins 26,941 98,698 19


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0001335Least InformativeDirect
Disease Ontology (DO)disease of mental health0.000001921Moderately InformativeDirect
Disease Ontology (DO)brain disease0.00002964Moderately InformativeDirect
Disease Ontology (DO)syndrome0.02291Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.745Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.000007842InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.0001547InformativeDirect
Disease Ontology (DO)peripheral nervous system disease0.5014InformativeInherited
Disease Ontology (DO)focal epilepsy0.6793InformativeInherited
Disease Ontology (DO)temporal lobe epilepsy0.00001515Highly InformativeDirect
Disease Ontology (DO)metal metabolism disorder0.003508Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.000000001249Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.03584Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2398Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.6893Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6991Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.9826Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.01205Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1016Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.1079Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1216Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.2356Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.3509Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.68Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.9037Moderately InformativeInherited
Phenotypic Abnormality (PA)Epileptic encephalopathy0.0000000003322InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.00001742InformativeDirect
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.00134InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.02152InformativeInherited
Phenotypic Abnormality (PA)Seizures0.03166InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.03674InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.5863InformativeInherited
Phenotypic Abnormality (PA)Abnormality of adrenal physiology0.588InformativeInherited
Phenotypic Abnormality (PA)Impairment in personality functioning0.6359InformativeInherited
Phenotypic Abnormality (PA)Abnormal atrioventricular conduction0.0000000000563Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.000000003705Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.000003145Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.00002615Highly InformativeDirect
Phenotypic Abnormality (PA)Febrile seizures0.0000428Highly InformativeDirect
Phenotypic Abnormality (PA)Metabolic alkalosis0.0001004Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0001951Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0001951Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0002603Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.002556Highly InformativeInherited
Phenotypic Abnormality (PA)Paralysis0.2787Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00003854Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2039Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.00000006419Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0.001646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.007639Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2938Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.3489Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.6889Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.0000003365InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.00000179InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.00003052InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.00006596InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.02114InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.03762InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.08198InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2695InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.8563InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission1InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.00000000000001741Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00000003188Highly InformativeDirect
Mammalian Phenotype (MP)muscle twitch0.00003425Highly InformativeDirect
Mammalian Phenotype (MP)decreased alcohol consumption0.0007679Highly InformativeDirect
Mammalian Phenotype (MP)abnormal exploration in a new environment0.0007959Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.005943Highly InformativeInherited
Mammalian Phenotype (MP)abnormal breathing pattern0.04107Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.1089Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.7576Highly InformativeInherited
Mammalian Phenotype (MP)abnormal reflex0.8363Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.002062Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.04007Least InformativeInherited
Worm Phenotype (WP)cell development variant0.481Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.8385Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.9517Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.9646Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.9992Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.002911Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.05215Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.07927Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.07927Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.07974Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.08023Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.1447Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1628Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.5189Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.7456Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.0000000008955InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.000001175InformativeDirect
Worm Phenotype (WP)body bend variant0.00003476InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00005145InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00005207InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.00006091InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0002215InformativeDirect
Worm Phenotype (WP)localized movement variant0.0003495InformativeDirect
Worm Phenotype (WP)body posture variant0.0004981InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0006154InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.001554InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.002581InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.04439InformativeInherited
Worm Phenotype (WP)egg laying variant0.0569InformativeInherited
Worm Phenotype (WP)defecation variant0.09486InformativeInherited
Worm Phenotype (WP)drug resistant0.1188InformativeInherited
Worm Phenotype (WP)directionality variant0.1904InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.3007InformativeInherited
Worm Phenotype (WP)small0.5519InformativeInherited
Worm Phenotype (WP)protein degradation variant0.00000008056Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.000002411Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.000002558Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000003386Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.000006725Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.000008725Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.00002178Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001084Highly InformativeDirect
Worm Phenotype (WP)short0.0001881Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0005991Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.003121Highly InformativeInherited
Worm Phenotype (WP)egg retention0.3004Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0007724Moderately InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.00009451InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.0009986InformativeDirect
Fly Phenotype (FP)chemical sensitive0.0008294Highly InformativeDirect
Fly Phenotype (FP)chemical resistant0.0008659Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.2971Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.5155Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1261Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3705Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0005624InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.01955InformativeInherited
Xenopus ANatomical entity (XAN)eye0.6094InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.00007633Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0001015Highly InformativeDirect
Xenopus ANatomical entity (XAN)cell part0.0003769Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0007507Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0000002874Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Voltage-gated potassium channels domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Voltage-gated potassium channels superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]