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Voltage-gated potassium channels superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Voltage-gated potassium channels [ 81325]
Superfamily:   Voltage-gated potassium channels [ 81324]
Families:   Voltage-gated potassium channels [ 81323] (5)


Superfamily statistics
Genomes (2,257) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 39,381 135,221 19
Proteins 26,941 98,698 19


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0001361Least InformativeDirect
Disease Ontology (DO)cardiovascular system disease0.515Least InformativeInherited
Disease Ontology (DO)disease of mental health0.00000192Moderately InformativeDirect
Disease Ontology (DO)brain disease0.00002905Moderately InformativeDirect
Disease Ontology (DO)syndrome0.02291Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.7451Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.000007831InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.0001636InformativeDirect
Disease Ontology (DO)peripheral nervous system disease0.5007InformativeInherited
Disease Ontology (DO)focal epilepsy0.6794InformativeInherited
Disease Ontology (DO)temporal lobe epilepsy0.00001513Highly InformativeDirect
Disease Ontology (DO)metal metabolism disorder0.003503Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.000000008941Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.05501Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2385Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.6023Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6876Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.9697Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.01138Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.07514Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1455Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1536Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.2109Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.349Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.6257Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.8739Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.8752Moderately InformativeInherited
Phenotypic Abnormality (PA)Epileptic encephalopathy0.0000000001826InformativeDirect
Phenotypic Abnormality (PA)Abnormal blood potassium concentration0.00006279InformativeDirect
Phenotypic Abnormality (PA)Arrhythmia0.00006843InformativeDirect
Phenotypic Abnormality (PA)Peripheral neuropathy0.03192InformativeInherited
Phenotypic Abnormality (PA)Seizures0.03958InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.5776InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.7041InformativeInherited
Phenotypic Abnormality (PA)Hypokalemia0.000003451Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.000006787Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.00001102Highly InformativeDirect
Phenotypic Abnormality (PA)EEG abnormality0.00006991Highly InformativeDirect
Phenotypic Abnormality (PA)Involuntary movements0.0000771Highly InformativeDirect
Phenotypic Abnormality (PA)Metabolic alkalosis0.0001063Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0001491Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0002047Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0002047Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.001682Highly InformativeInherited
Phenotypic Abnormality (PA)Paralysis0.2877Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00003908Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2042Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.00000006208Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0.001644Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.007626Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2935Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.3485Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.6884Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.0000003324InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000001766InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.00003049InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.00006592InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.02135InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.03758InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.08152InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2695InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.8558InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission1InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.00000000000001742Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00000003182Highly InformativeDirect
Mammalian Phenotype (MP)muscle twitch0.00003422Highly InformativeDirect
Mammalian Phenotype (MP)decreased alcohol consumption0.0007684Highly InformativeDirect
Mammalian Phenotype (MP)abnormal exploration in a new environment0.0007961Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.005944Highly InformativeInherited
Mammalian Phenotype (MP)abnormal breathing pattern0.04101Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.109Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.7578Highly InformativeInherited
Mammalian Phenotype (MP)abnormal reflex0.8364Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.001336Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.03837Least InformativeInherited
Worm Phenotype (WP)cell development variant0.4256Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.8412Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.9038Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.9373Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.0003589Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.008603Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.03038Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1025Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.1661Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.5692Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.8132Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.0000000008535InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000000766InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.000001121InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.00003251InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00004963InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00005153InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.00006722InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0002128InformativeDirect
Worm Phenotype (WP)localized movement variant0.0003384InformativeDirect
Worm Phenotype (WP)body posture variant0.0005797InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0007801InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.001505InformativeInherited
Worm Phenotype (WP)body length variant0.003803InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.0456InformativeInherited
Worm Phenotype (WP)egg laying variant0.06792InformativeInherited
Worm Phenotype (WP)defecation variant0.1037InformativeInherited
Worm Phenotype (WP)body width variant0.2415InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.3034InformativeInherited
Worm Phenotype (WP)growth rate variant0.000002299Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.000002445Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000003244Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.000006432Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.000008357Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.00002122Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001185Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0005778Highly InformativeDirect
Worm Phenotype (WP)serotonin response variant0.0008971Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.003074Highly InformativeInherited
Worm Phenotype (WP)egg retention0.3031Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0007564Moderately InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.00008414InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.0009495InformativeDirect
Fly Phenotype (FP)sensory perception defective0.0009833InformativeDirect
Fly Phenotype (FP)chemical resistant0.000868Highly InformativeDirect
Fly Phenotype (FP)chemical sensitive0.000893Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.2964Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4892Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1032Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3526Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0003024InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.01593InformativeInherited
Xenopus ANatomical entity (XAN)eye0.5956InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.00006917Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0007168Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal neural layer0.0009848Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0000002873Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)early tailbud stage0.04194Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Voltage-gated potassium channels domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Voltage-gated potassium channels superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]