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Aquaporin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Families:   Aquaporin-like [ 56895] (4)


Superfamily statistics
Genomes (2,153) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,999 31,610 8
Proteins 8,878 31,387 8


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.072480.4829Least InformativeInherited
Biological Process (BP)biological regulation0.40471Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00040170.4808Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0000033510.2643Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)response to abiotic stimulus0.000000094370.00000303Moderately InformativeDirect
Biological Process (BP)single-organism transport0.000005430.00000001559Moderately InformativeDirect
Biological Process (BP)protein complex biogenesis0.0000047660.0000001426Moderately InformativeDirect
Biological Process (BP)response to organic substance0.16221Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.092380.2958Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.029280.00005416Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0000020190.003023Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.025420.3089Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00011380.005933Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00012570.003437Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.27130.5194Moderately InformativeInherited
Biological Process (BP)multi-organism process0.018120.247Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.36620.02601Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.00045060.07147Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.68541Moderately InformativeInherited
Biological Process (BP)regulation of localization0.052530.8288Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.15160.2363Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process0.0036880.004399Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.02671Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.020131Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.031310.55Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)animal organ development0.0046890.6765Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport11Moderately InformativeInherited
Biological Process (BP)organic substance transport10.6302Moderately InformativeInherited
Biological Process (BP)ion transport11Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.012550.01898Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.17750.3463Moderately InformativeInherited
Biological Process (BP)purine-containing compound metabolic process0.0022980.004273Moderately InformativeInherited
Biological Process (BP)response to acid chemical0.00000000078630.0000000002242InformativeDirect
Biological Process (BP)system process0.000000020760.00000000006138InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.000016550.00004InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.00000032990.000002296InformativeDirect
Biological Process (BP)protein oligomerization0.0000000048290.000000000001752InformativeDirect
Biological Process (BP)transmembrane transport0.00029590.0002803InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.0000012690.000005151InformativeDirect
Biological Process (BP)regulation of anatomical structure size0.0000052790.0002155InformativeDirect
Biological Process (BP)positive regulation of developmental process0.0035790.291InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.0085140.01592InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.0063250.07899InformativeInherited
Biological Process (BP)response to nitrogen compound0.00075640.1864InformativeInherited
Biological Process (BP)cellular response to lipid0.0090810.003256InformativeInherited
Biological Process (BP)response to organic cyclic compound0.00058190.002984InformativeInherited
Biological Process (BP)response to metal ion0.40990.7196InformativeInherited
Biological Process (BP)cellular response to inorganic substance0.0010120.0001438InformativeInherited
Biological Process (BP)response to oxidative stress0.017840.03846InformativeInherited
Biological Process (BP)interspecies interaction between organisms0.025270.03744InformativeInherited
Biological Process (BP)regulation of cell proliferation0.0038030.3291InformativeInherited
Biological Process (BP)positive regulation of transport0.001380.01627InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.032840.4998InformativeInherited
Biological Process (BP)regulation of secretion0.002410.008257InformativeInherited
Biological Process (BP)regulation of system process0.000011630.001769InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0017140.1448InformativeInherited
Biological Process (BP)actin cytoskeleton organization0.0000042290.003925InformativeInherited
Biological Process (BP)central nervous system development0.017650.1451InformativeInherited
Biological Process (BP)response to radiation0.44490.7676InformativeInherited
Biological Process (BP)response to hypoxia0.0000010830.00002989Highly InformativeDirect
Biological Process (BP)response to osmotic stress0.000000000019580.00000000000008102Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity0.0000000080.0001227Highly InformativeDirect
Biological Process (BP)regulation of cell size0.00000000000088270.000000185Highly InformativeDirect
Biological Process (BP)response to UV0.0000000026570.000001334Highly InformativeDirect
Biological Process (BP)response to water deprivation0.00010480.00000001495Highly InformativeDirect
Biological Process (BP)response to mechanical stimulus0.000000068250.0001205Highly InformativeDirect
Biological Process (BP)response to purine-containing compound0.00000000082380.000000003597Highly InformativeDirect
Biological Process (BP)gas transport0.0000095940.00000000001057Highly InformativeDirect
Biological Process (BP)ammonium transport0.00013350.000001184Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.0000000000000031440Highly InformativeDirect
Biological Process (BP)one-carbon compound transport00Highly InformativeDirect
Biological Process (BP)forebrain development0.000000090640.00008272Highly InformativeDirect
Biological Process (BP)response to retinoic acid0.0000000030760.00000007224Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species0.000069510.000005746Highly InformativeDirect
Biological Process (BP)cellular response to decreased oxygen levels0.000056290.0001002Highly InformativeDirect
Biological Process (BP)response to estrogen0.0000012320.00001422Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.000000010090.00000008224Highly InformativeDirect
Biological Process (BP)positive regulation of cell adhesion0.000000022280.000003915Highly InformativeDirect
Biological Process (BP)response to organophosphorus0.000000000044850.0000000003975Highly InformativeDirect
Biological Process (BP)response to copper ion0.0000089150.000001657Highly InformativeDirect
Biological Process (BP)regulation of fibroblast proliferation0.0000000000011670.000000000332Highly InformativeDirect
Biological Process (BP)multicellular organismal homeostasis0.0000000090460.000000000003282Highly InformativeDirect
Biological Process (BP)response to glucocorticoid0.000000024030.000000007729Highly InformativeDirect
Biological Process (BP)interaction with symbiont0.0000000000044330.00000000001864Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction0.000000022410.000003946Highly InformativeDirect
Biological Process (BP)cellular response to abiotic stimulus0.000000001410.000001542Highly InformativeDirect
Biological Process (BP)cellular response to acid chemical0.000014870.0001092Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus0.0000004110.000001017Highly InformativeDirect
Biological Process (BP)cellular response to organonitrogen compound0.000000012420.00004837Highly InformativeDirect
Biological Process (BP)response to ketone0.00000088250.0001708Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide0.00023910.004085Highly InformativeInherited
Biological Process (BP)camera-type eye development0.00000056910.001608Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)monovalent inorganic cation transmembrane transporter activity0.000006260.0006274InformativeDirect
Molecular Function (MF)passive transmembrane transporter activity00InformativeDirect
Molecular Function (MF)molecular transducer activity0.0032050.4299InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.66570.0003494InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.000000076210.001245InformativeInherited
Molecular Function (MF)ammonium transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)inorganic anion transmembrane transporter activity0.00089850.000149Highly InformativeDirect
Molecular Function (MF)amide transmembrane transporter activity0.00011750.0000000000995Highly InformativeDirect
Molecular Function (MF)organic hydroxy compound transmembrane transporter activity0.00000013540Highly InformativeDirect
Molecular Function (MF)gated channel activity11Highly InformativeInherited
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0016270.0000000000002261Highly InformativeInherited
Molecular Function (MF)ion channel activity0.036581Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.26581Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.9386Least InformativeInherited
Cellular Component (CC)vacuole0.000000014490.000000001305Moderately InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)cell projection0.00036720.006895Moderately InformativeInherited
Cellular Component (CC)nuclear part0.35881Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.038060.2171Moderately InformativeInherited
Cellular Component (CC)whole membrane0.11820.8976Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.00095640.01503Moderately InformativeInherited
Cellular Component (CC)nuclear envelope0.000035450.0001063InformativeDirect
Cellular Component (CC)vacuolar part0.0000000021090.000000101InformativeDirect
Cellular Component (CC)apical part of cell00InformativeDirect
Cellular Component (CC)plasma membrane region00.000000000000005967InformativeDirect
Cellular Component (CC)plasma membrane bounded cell projection part0.040230.02344InformativeInherited
Cellular Component (CC)apical plasma membrane0.0000000000090740.0000000000002671Highly InformativeDirect
Cellular Component (CC)brush border membrane00.00000000007092Highly InformativeDirect
Cellular Component (CC)nuclear membrane0.000000055030.0000003328Highly InformativeDirect
Cellular Component (CC)basal part of cell00Highly InformativeDirect
Cellular Component (CC)symplast0.00021050.0001209Highly InformativeDirect
Cellular Component (CC)basolateral plasma membrane0.021040.01973Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4829 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4808 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2643 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.00000303 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00005416 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.00000001559 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0000001426 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.2958 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.003023 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.3089 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.005933 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.003437 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.5194 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.247 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.02601 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.07147 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8288 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.2363 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.004399 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.55 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.6765 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6302 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.01898 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.3463 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.004273 Moderately Informative Inherited
Biological Process (BP) response to acid chemical 0.0000000002242 Informative Direct
Biological Process (BP) system process 0.00000000006138 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00004 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.000002296 Informative Direct
Biological Process (BP) protein oligomerization 0.000000000001752 Informative Direct
Biological Process (BP) transmembrane transport 0.0002803 Informative Direct
Biological Process (BP) cellular response to inorganic substance 0.0001438 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.000005151 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0002155 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.291 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.01592 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07899 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.1864 Informative Inherited
Biological Process (BP) cellular response to lipid 0.003256 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.002984 Informative Inherited
Biological Process (BP) response to metal ion 0.7196 Informative Inherited
Biological Process (BP) response to oxidative stress 0.03846 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.03744 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.3291 Informative Inherited
Biological Process (BP) positive regulation of transport 0.01627 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4998 Informative Inherited
Biological Process (BP) regulation of secretion 0.008257 Informative Inherited
Biological Process (BP) regulation of system process 0.001769 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1448 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.003925 Informative Inherited
Biological Process (BP) central nervous system development 0.1451 Informative Inherited
Biological Process (BP) response to radiation 0.7676 Informative Inherited
Biological Process (BP) response to hypoxia 0.00002989 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0.00000000000008102 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0001227 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.000000185 Highly Informative Direct
Biological Process (BP) response to UV 0.000001334 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.00000001495 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.0001205 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000003597 Highly Informative Direct
Biological Process (BP) gas transport 0.00000000001057 Highly Informative Direct
Biological Process (BP) ammonium transport 0.000001184 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0 Highly Informative Direct
Biological Process (BP) forebrain development 0.00008272 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.00000007224 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.000005746 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.0001002 Highly Informative Direct
Biological Process (BP) response to estrogen 0.00001422 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.00000008224 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000003915 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0000000003975 Highly Informative Direct
Biological Process (BP) response to copper ion 0.000001657 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.000000000332 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.000000000003282 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.0001649 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.000000007729 Highly Informative Direct
Biological Process (BP) interaction with symbiont 0.00000000001864 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.000003946 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.000001542 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.0001092 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.000001017 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00004837 Highly Informative Direct
Biological Process (BP) response to ketone 0.0001708 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.004085 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.001608 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.0003494 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0006274 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.4299 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.001245 Informative Inherited
Molecular Function (MF) ammonium transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.000149 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0.0000000000002261 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.0000000000995 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9386 Least Informative Inherited
Cellular Component (CC) vacuole 0.000000001305 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.006895 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.2171 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.8976 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.01503 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.0001063 Informative Direct
Cellular Component (CC) vacuolar part 0.000000101 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000000000005967 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.02344 Informative Inherited
Cellular Component (CC) apical plasma membrane 0.0000000000002671 Highly Informative Direct
Cellular Component (CC) brush border membrane 0.00000000007092 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0000003328 Highly Informative Direct
Cellular Component (CC) basal part of cell 0 Highly Informative Direct
Cellular Component (CC) symplast 0.0001209 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.01973 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processStress response0.000008736InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle0.00000000000007398Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000001774Moderately InformativeDirect
Cellular componentCell junction0.000216Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationGlycoprotein0.000004868Least InformativeDirect
Post-translational modificationPhosphoprotein0.0004952Least InformativeDirect
Post-translational modificationAcetylation0.0009692Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000425 SSF81338 Protein matches
Abstract

A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities [PubMed8325040, PubMed2014003, PubMed1715617, PubMed7529436].

These include:

  • Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions.
  • Mammalian aquaporins [PubMed7529436]. These proteins form water- specific channels that provide the plasma membranes of red cells and kidney prox imal and collecting tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Soybean nodulin-26, a major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection.
  • Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP : alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins may allow the diffusion of water, amino acids and/or peptides from the tonoplas t interior to the cytoplasm..
  • Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo vement of glycerol across the cytoplasmic membrane.
  • Salmonella typhimurium propanediol diffusion fac ilitator (gene pduF).
  • Yeast FPS1, a glycerol uptake/efflux facilitator protein.
  • Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in tercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an ep idermoblast instead of a neuroblast.
  • Yeast hypothetical protein YFL054c.
  • A hypothetical protein from the pepX region of Lactococ cus lactis.

MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem, intragenic duplication from an ancestral protein that contained 3 TM domains [].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates a ttached to lipids or proteins [PubMed11845000]. Aquaporin-CHIP (Aquaporin 1) belo ngs to the Colton blood group system and is associated with Co(a/b) antigen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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