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Clc chloride channel superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Clc chloride channel [ 81341]
Superfamily:   Clc chloride channel [ 81340]
Families:   Clc chloride channel [ 69912]


Superfamily statistics
Genomes (2,139) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,141 26,132 14
Proteins 6,044 25,951 14


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.5831 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6186 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.04574 Least Informative Inherited
Biological Process (BP) ion transport 0.000000000000148 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000001864 Moderately Informative Direct
Biological Process (BP) organelle organization 0.39 Moderately Informative Inherited
Biological Process (BP) transmembrane transport 0.00000001489 Informative Direct
Biological Process (BP) system process 0.0000001542 Informative Direct
Biological Process (BP) anion transport 0.00004975 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.425 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.6248 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) pH reduction 0.00000000008137 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 0.000000001743 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0000006193 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.001405 Highly Informative Inherited
Molecular Function (MF) binding 0.6828 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.000000000006479 Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0.000000000003878 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.00000000002916 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000001706 Highly Informative Direct
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.00000000000000156 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001301 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.2985 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.00000003887 Moderately Informative Direct
Cellular Component (CC) vacuole 0.0000002172 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000001119 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.02203 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.04948 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.6735 Moderately Informative Inherited
Cellular Component (CC) endosome 0.00000001217 Informative Direct
Cellular Component (CC) vacuolar part 0.0000005111 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0000006094 Informative Direct
Cellular Component (CC) apical part of cell 0.0001087 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processAntiport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentGolgi apparatus0.000006703Moderately InformativeDirect
Cellular componentCell membrane0.000006861Moderately InformativeDirect
DiseaseDisease mutation0.000007901Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainRepeat0.0007999Least InformativeDirect
DomainCBS domain0Highly InformativeDirect
Molecular functionChloride0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0.000000001167Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR014743 SSF81340 Protein matches
Abstract

This entry represents the core domain of the cholide ion channel.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Clc chloride channel domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Clc chloride channel superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]