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ISP transmembrane anchor superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Single transmembrane helix [ 81407] (38)
Superfamily:   ISP transmembrane anchor [ 81502]
Families:   ISP transmembrane anchor [ 81501] (2)


Superfamily statistics
Genomes (450) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 623 1,684 4
Proteins 623 1,680 4


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000004239 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0007322 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.005875 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.05555 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.05018 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.03715 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.03464 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000000006648 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00000000000003926 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.000000001248 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000005082 Moderately Informative Direct
Biological Process (BP) phosphorylation 0.0000003225 Informative Direct
Biological Process (BP) electron transport chain 0.00000000001263 Informative Direct
Biological Process (BP) cellular respiration 0 Informative Direct
Biological Process (BP) ATP metabolic process 0.000000000008983 Informative Direct
Molecular Function (MF) transporter activity 0.000000007514 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.000000007073 Moderately Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0000000000000108 Informative Direct
Cellular Component (CC) membrane 0.000001338 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000007036 Least Informative Direct
Cellular Component (CC) protein complex 0.00000003785 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000002203 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0005261 Least Informative Direct
Cellular Component (CC) mitochondrial envelope 0 Moderately Informative Direct
Cellular Component (CC) organelle inner membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.000000000362 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.00000000000006858 Moderately Informative Direct
Cellular Component (CC) mitochondrial protein complex 0.00000000001023 Moderately Informative Direct
Cellular Component (CC) mitochondrial respiratory chain 0.000000864 Informative Direct
Cellular Component (CC) cytochrome complex 0 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.0000002455 Informative Direct
Cellular Component (CC) respiratory chain complex 0 Informative Direct
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) mitochondrial respiratory chain complex III 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processRespiratory chain0.00000000007901Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionIron-sulfur0Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR004192 SSF81502 Protein matches
Abstract The ubiquinol cytochrome c reductase (cytochrome bc1) complex is a respiratory chain that generates an elctrochemical potential coupled to ATP synthesis. The bc1 complex contains 11 subunits, 3 respiratory subunits (cytochrome B, cytochrome C1, Rieske protein), 2 core proteins and 6 low-molecular weight proteins. Each subunit of the cytochrome bc1 complex provides a single helix (this family) to make up the transmembrane region of the complex.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ISP transmembrane anchor domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the ISP transmembrane anchor superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]