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HCP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   HCP-like [ 81901]
Families:   HCP-like [ 81902] (2)


Superfamily statistics
Genomes (2,161) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 21,976 90,342 2
Proteins 16,843 67,462 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.9589 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.1298 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9828 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8388 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7105 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3211 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6002 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.1635 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.6713 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1112 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.4326 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2276 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.3242 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.001057 Informative Inherited
Biological Process (BP) proteolysis 0.06023 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.06839 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.03361 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.003096 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.007905 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.7691 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.9077 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8625 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.9497 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1228 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.3005 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.1167 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.4612 Informative Inherited
Biological Process (BP) embryo development 0.05119 Informative Inherited
Biological Process (BP) gastrulation 0.0004514 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0002164 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00001493 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.416 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.001672 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.006084 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.00114 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.8575 Least Informative Inherited
Cellular Component (CC) protein complex 0.3006 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0.00000029 Moderately Informative Direct
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00001519 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.2936 Informative Inherited
Cellular Component (CC) chromosome 0.08658 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.03668 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.001503 Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.0000000001523 Highly Informative Direct
Cellular Component (CC) chromatin 0.00311 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In cyclic amides0InformativeDirect
Enzyme Commission (EC)Beta-lactamase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0.0000000007567InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0005075Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransit peptide0.00000000000007424Moderately InformativeDirect
DomainTPR repeat0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HCP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the HCP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]