SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


Obg GTP-binding protein N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Obg-fold [ 82050]
Superfamily:   Obg GTP-binding protein N-terminal domain [ 82051]
Families:   Obg GTP-binding protein N-terminal domain [ 82052]


Superfamily statistics
Genomes (3,043) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,506 16,979 2
Proteins 3,488 16,935 2


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)cytoplasmic part00.0001008Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle00.1727Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.0851 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1261 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.09183 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.1882 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1579 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.000113 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0004326 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0005443 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.006481 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.003294 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01378 Moderately Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.000001247 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000001877 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000002527 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.000003532 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.000003745 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00001546 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00003618 Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.0000000009952 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.000000535 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.0000005717 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0000007231 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.0000007975 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.0000008307 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0244 Least Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.00002264 Informative Direct
Cellular Component (CC) cytoplasmic part 0.0001008 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.9309 Least Informative Inherited
Cellular Component (CC) membrane 0.3893 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1727 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.000779 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.005391 Moderately Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006169 SSF82051 Protein matches
Abstract

Several proteins have recently been shown to contain the 5 structural motifs characteristic of GTP-binding proteins [PubMed1449490]. These include murine DRG protein; GTP1 protein from Schizosaccharomyces pombe; OBG protein from Bacillus subtilis; and several others. Although the proteins contain GTP-binding motifs and are similar to each other, they do not share sequence similarity to other GTP-binding proteins, and have thus been classed as a novel group, the GTP1/OBG family. As yet, the functions of these proteins is uncertain, but they have been shown to be important in development and normal cell metabolism [PubMed8462872, PubMed2537815].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Obg GTP-binding protein N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Obg GTP-binding protein N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]