SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


MIR domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   MIR domain [ 82109]
Family:   MIR domain [ 82110] (2)


Family statistics
Genomes (254) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 736 2,072 2
Proteins 733 2,065 2


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Heterogeneous0.0002301InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1543Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1683Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.4208Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.4306Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4592Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6537Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7524Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.04731Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.06857Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.1009Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1016Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1796Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2002Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.2209Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2357Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.2364Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.3069Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.001761InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.01207InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.03458InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.03569InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.08882InformativeInherited
Phenotypic Abnormality (PA)Abnormal palate morphology0.09731InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.1982InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.3653InformativeInherited
Phenotypic Abnormality (PA)Abnormal synaptic transmission at the neuromuscular junction1InformativeInherited
Phenotypic Abnormality (PA)Left ventricular dysfunction0.00001368Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.00003866Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.00005939Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the lower limbs0.00009167Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the uvula0.0002262Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0.0002909Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the cerebellar vermis0.0007853Highly InformativeDirect
Phenotypic Abnormality (PA)Proximal muscle weakness0.0009798Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal left ventricle morphology0.007033Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.01776Highly InformativeInherited
Phenotypic Abnormality (PA)Respiratory insufficiency0.01808Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pinna0.03041Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.08236Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.00003183Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal pancreas physiology0.001163InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)muscle cell0InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.6711Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.07756Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.124Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle0.001028InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.00449InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a MIR domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]