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FAS1 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   FAS1 domain [ 82152]
Superfamily:   FAS1 domain [ 82153]
Families:   FAS1 domain [ 82154] (2)


Superfamily statistics
Genomes (924) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,120 26,962 3
Proteins 4,554 16,242 2


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00000001699 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0006404 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01079 Least Informative Inherited
Biological Process (BP) response to stimulus 0.6339 Least Informative Inherited
Biological Process (BP) reproduction 0.00000001685 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0000000000009434 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.02279 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04464 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.02261 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.003687 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.609 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.003934 Moderately Informative Inherited
Biological Process (BP) tissue development 0.05741 Moderately Informative Inherited
Biological Process (BP) response to acid chemical 0.0002943 Informative Direct
Biological Process (BP) post-embryonic development 0.0009057 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00008755 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.0000003178 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000241 Informative Direct
Biological Process (BP) generation of neurons 0.0001358 Informative Direct
Biological Process (BP) reproductive system development 0.0007234 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.03042 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.008785 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) circulatory system development 0.6765 Informative Inherited
Biological Process (BP) cell development 0.07463 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001078 Informative Inherited
Biological Process (BP) growth 0.006128 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.03064 Informative Inherited
Biological Process (BP) response to osmotic stress 0.000004963 Highly Informative Direct
Biological Process (BP) muscle organ development 0.00004417 Highly Informative Direct
Biological Process (BP) trichome differentiation 0.0000000000002588 Highly Informative Direct
Biological Process (BP) cell growth 0.00004905 Highly Informative Direct
Biological Process (BP) biological adhesion 0.000203 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.000000004107 Highly Informative Direct
Biological Process (BP) seed development 0.00000000001002 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0006271 Highly Informative Direct
Biological Process (BP) response to alcohol 0.00003702 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00004659 Highly Informative Direct
Biological Process (BP) neuron development 0.03175 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.4037 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.02226 Moderately Informative Inherited
Cellular Component (CC) membrane 0.00005132 Least Informative Direct
Cellular Component (CC) plasma membrane 0.000004597 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0001389 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.000003491 Moderately Informative Direct
Cellular Component (CC) anchored component of membrane 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.09789 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0.0000000000002031InformativeDirect
Cellular componentMembrane0.00001409Least InformativeDirect
Cellular componentSecreted0.00000001438Moderately InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentExtracellular matrix0.000001085InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.0002228Least InformativeDirect
DomainEGF-like domain0.00002535InformativeDirect
DomainLaminin EGF-like domain0.00000000003075Highly InformativeDirect
Post-translational modificationReceptor0.0005176Moderately InformativeDirect
Post-translational modificationGlycoprotein9.634e-16Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0.000000000000124Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000782 SSF82153 Protein matches
Abstract

The FAS1 or BIgH3 domain is an extracellular module of about 140 amino acid residues. It has been suggested that the FAS1 domain represents an ancient cell adhesion domain common to plants and animals [PubMed7925267]; related FAS1 domains are also found in bacteria [PubMed7822037]. Most FAS1 domain containing proteins are GPI anchored and contain two or four copies of the domain. FAS1 domains of BIgH3 protein mediate cell adhesion throught an interaction with alpha3/beta1 integrin. A short motif (EPDIM), located on the C-teminal side of the fourth domain, is essential for the binding to integrin [PubMed10906123]. The crystal structure of two FAS1 domains (FAS1 3-4) of a fas1 protein have been solved [PubMed12575939]. Each domain consists of seven-stranded wedge and at least five alpha helices. Two well-ordered N-acetylglucosamine moities attached to a conserved asparagine are located in the interface region between the two FAS1 domains.

Some of the proteins containing a FAS1 domain are listed below:
  • Drosophila fasciclin I (fas1) protein. A cell adhesion molecule involved in axon guidance. It is attached to the membrane by a GPI-anchor (4 copies).
  • Human TGF-beta induced Ig-H3 (BIgH3) protein. Mutation in its FAS1 domains result in corneal distrophy, due to the deposition of insoluble protein aggregates (4 copies).
  • Arabidopsis fasciclin-like arabinogalactan proteins (2 copies).
  • Volvox major cell adhesion protein (2 copies).
  • Bacterial immunogenic protein MPT70 (1 copy).
  • Human extracellular matrix protein periostin (4 copies).
  • Mammalian stabilin protein (7 copies).

  • InterPro database


    PDBeMotif information about ligands, sequence and structure motifs
    Cross references PDB entries
    Ligand binding statistics
    Nucleic-acid binding statistics
    Occurrence of secondary structure elements
    Occurrence of small 3D structural motifs

    PDBeMotif resource

    Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

    Internal database links

    Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


    Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


    Browse and view proteins in genomes which have different domain combinations including a FAS1 domain domain.


    Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


    Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

    There are 3 hidden Markov models representing the FAS1 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


    Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]