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Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   open-sided beta-meander [ 51086] (2)
Superfamily:   Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82185]
Families:   Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82186]


Superfamily statistics
Genomes (1,052) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 10,625 35,558 8
Proteins 6,226 21,167 8


Functional annotation
General category Information
Detailed category Chromatin structure

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.13621Least InformativeInherited
Biological Process (BP)response to wounding0.00000064710.002078InformativeInherited
Biological Process (BP)response to axon injury0.000000000047750.000000016Highly InformativeDirect
Cellular Component (CC)cell projection0.000010940.0000004006Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) regulation of signaling 0.04917 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.04816 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.6228 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.001241 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.0683 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.5487 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1936 Moderately Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.0003676 Informative Direct
Biological Process (BP) regulation of ion transport 0.0003359 Informative Direct
Biological Process (BP) regulation of cellular localization 0.01018 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.02379 Informative Inherited
Biological Process (BP) response to wounding 0.002078 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.05021 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.004117 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.003869 Informative Inherited
Biological Process (BP) cation homeostasis 0.00139 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.001515 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.001305 Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.00003848 Highly Informative Direct
Biological Process (BP) protein alkylation 0.000003523 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.00008802 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.000001289 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.00001771 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.00008192 Highly Informative Direct
Biological Process (BP) response to axon injury 0.000000016 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.00000003359 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0002759 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.0000000657 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.000005503 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.000001321 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.1073 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.2989 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.007001 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0005139 Informative Direct
Molecular Function (MF) enzyme binding 0.0246 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.02467 Informative Inherited
Molecular Function (MF) kinase activity 0.0418 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00000003977 Highly Informative Direct
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.0000291 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.000001751 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.873 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.04926 Least Informative Inherited
Cellular Component (CC) protein complex 0.02607 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.7089 Least Informative Inherited
Cellular Component (CC) membrane 0.2498 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000004006 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0127 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.08974 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.0003367 Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.1114Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0000001562Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0001651Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000000002584InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentEndoplasmic reticulum0.00000000002882Moderately InformativeDirect
Cellular componentChromosome0.0000003113InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationTransferase0.2535Least InformativeInherited
Post-translational modificationKinase0.0001011Moderately InformativeDirect
Post-translational modificationActivator0.00059Moderately InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000000008889InformativeDirect
Post-translational modificationChromatin regulator0.000001796InformativeDirect
Post-translational modificationPhosphoprotein0.000299Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]