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Multidrug efflux transporter AcrB transmembrane domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Multidrug efflux transporter AcrB transmembrane domain [ 82865]
Superfamily:   Multidrug efflux transporter AcrB transmembrane domain [ 82866]
Families:   Multidrug efflux transporter AcrB transmembrane domain [ 82867]


Superfamily statistics
Genomes (2,965) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 38,206 341,257 4
Proteins 21,625 194,271 2


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Hydroxymethylglutaryl-CoA reductase (NADPH)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.004978Moderately InformativeInherited
Disease Ontology (DO)coronary artery disease0.0000948InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Heterogeneous0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.632Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0155Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01634Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.000872InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.001963InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.004117InformativeInherited
Mammalian Phenotype (MP)decreased cholesterol level0.00009416Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000000000001062Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.2168Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2226Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000006546Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00001808Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.00741Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.301Moderately InformativeInherited
Worm Phenotype (WP)body length variant0InformativeDirect
Worm Phenotype (WP)body width variant0InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0001171InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0Highly InformativeDirect
Worm Phenotype (WP)body vacuole0Highly InformativeDirect
Worm Phenotype (WP)molt variant0Highly InformativeDirect
Worm Phenotype (WP)small0.000000000006698Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.00000000007539Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant0.000000004347Highly InformativeDirect
Worm Phenotype (WP)osmotic integrity variant0.002265Highly InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.06938Highly InformativeInherited
Worm Phenotype (WP)alae morphology variant0.1479Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.02889Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.006824InformativeInherited
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0006748Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.08487Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.4828Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.5163Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.5884Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.8962Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.18Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.1889Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.2088Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.3289Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.7923Moderately InformativeInherited
Zebrafish Anatomy (ZA)musculature system0.00553InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.02779InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.04802InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.06129InformativeInherited
Zebrafish Anatomy (ZA)eye0.0972InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle cell0.00006814Highly InformativeDirect
Zebrafish Anatomy (ZA)suspensorium0.001328Highly InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch 2 skeleton0.003501Highly InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch cartilage0.009065Highly InformativeInherited
Zebrafish Anatomy (ZA)retinal neural layer0.01002Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Multidrug efflux transporter AcrB transmembrane domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Multidrug efflux transporter AcrB transmembrane domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]