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Multidrug efflux transporter AcrB transmembrane domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Multidrug efflux transporter AcrB transmembrane domain [ 82865]
Superfamily:   Multidrug efflux transporter AcrB transmembrane domain [ 82866]
Families:   Multidrug efflux transporter AcrB transmembrane domain [ 82867]


Superfamily statistics
Genomes (2,965) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 38,206 252,691 4
Proteins 21,625 143,974 2


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000000005632 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.9512 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9245 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1744 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2415 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.000000002072 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00008326 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.8319 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.7891 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1272 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2007 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2498 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.2962 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6046 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01539 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0338 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002012 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2108 Moderately Informative Inherited
Biological Process (BP) gene expression 0.8663 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2021 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9731 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7361 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2908 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.5778 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02196 Moderately Informative Inherited
Biological Process (BP) cell communication 0.3762 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2313 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.000000005475 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0001735 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0003293 Informative Direct
Biological Process (BP) alcohol metabolic process 0.0529 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.003416 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.005607 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.005631 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.02493 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.002068 Informative Inherited
Biological Process (BP) proteolysis 0.1917 Informative Inherited
Biological Process (BP) secretion by cell 0.01357 Informative Inherited
Biological Process (BP) protein transport 1 Informative Inherited
Biological Process (BP) cell development 0.2335 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6804 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.949 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.004173 Informative Inherited
Biological Process (BP) intracellular transport 0.7843 Informative Inherited
Biological Process (BP) transmembrane transport 0.2593 Informative Inherited
Biological Process (BP) response to drug 0.00000000005408 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.00000009961 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.000002525 Highly Informative Direct
Biological Process (BP) regulation of lipid localization 0.000004315 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0.000004538 Highly Informative Direct
Biological Process (BP) protein maturation 0.00002677 Highly Informative Direct
Biological Process (BP) protein secretion 0.0004634 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0006296 Highly Informative Direct
Biological Process (BP) sex differentiation 0.02759 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.01323 Highly Informative Inherited
Biological Process (BP) germ cell development 0.1857 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.00000000001136 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.796 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.1821 Moderately Informative Inherited
Molecular Function (MF) drug transporter activity 0.00000000542 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00000001972 Highly Informative Direct
Molecular Function (MF) steroid binding 0.0000002218 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.001687 Highly Informative Inherited
Cellular Component (CC) membrane 0.000000005787 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9826 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.0000000002684 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.002134 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.009257 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.5325 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.00000000001641 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0000002865 Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000000005453 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0007958 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Hydroxymethylglutaryl-CoA reductase (NADPH)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processLipid metabolism0.00008576Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processAntibiotic resistance0.00001692InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processTranslocation0Highly InformativeDirect
Biological processSteroid biosynthesis0.00000000007188Highly InformativeDirect
Biological processSterol biosynthesis1Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001089Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0002057Moderately InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationGlycoprotein0.000000002478Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Multidrug efflux transporter AcrB transmembrane domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Multidrug efflux transporter AcrB transmembrane domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]