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Multidrug efflux transporter AcrB transmembrane domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Multidrug efflux transporter AcrB transmembrane domain [ 82865]
Superfamily:   Multidrug efflux transporter AcrB transmembrane domain [ 82866]
Family:   Multidrug efflux transporter AcrB transmembrane domain [ 82867]


Family statistics
Genomes (1,635) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,775 105,285 4
Proteins 6,642 60,870 2


Disease Ontology (DO)

(
show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Heterogeneous0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebrum0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.01691Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal conjugate eye movement0InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Abnormal uvea morphology0.001245InformativeInherited
Phenotypic Abnormality (PA)Coloboma0.00005396Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality iris morphology0.0004657Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.06073Least InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.002109Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.008505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.01409Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal diencephalon morphology0.00002657Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0000000000146Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.3157Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3182Least InformativeInherited
Worm Phenotype (WP)body region morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000007222Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00001214Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.06154Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.3438Moderately InformativeInherited
Worm Phenotype (WP)small0InformativeDirect
Worm Phenotype (WP)vulva morphology variant0InformativeDirect
Worm Phenotype (WP)chemosensory response variant0.002456InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0Highly InformativeDirect
Worm Phenotype (WP)molt variant0Highly InformativeDirect
Worm Phenotype (WP)pericellular component physiology variant0.00000000009798Highly InformativeDirect
Worm Phenotype (WP)body region development variant0.000000001212Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant0.00000000711Highly InformativeDirect
Worm Phenotype (WP)cuticle morphology variant0.000001336Highly InformativeDirect
Worm Phenotype (WP)epithelial system physiology variant0.00001298Highly InformativeDirect
Worm Phenotype (WP)positive chemotaxis defective0.0001168Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.06783Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.1317Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.1536Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.1645Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2296Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.253Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.3014Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.007593Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.02589Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.06285Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.1208Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle0.0003823InformativeDirect
Zebrafish Anatomy (ZA)pharyngeal arch0.009509InformativeInherited
Zebrafish Anatomy (ZA)eye0.01154InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.01417InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.0284InformativeInherited
Zebrafish Anatomy (ZA)slow muscle cell0.00001232Highly InformativeDirect
Zebrafish Anatomy (ZA)pharyngeal arch cartilage0.001327Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.4134Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7201Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1515Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.6364Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.01967InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.07143InformativeInherited
Xenopus ANatomical entity (XAN)epidermis0.0003683Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Multidrug efflux transporter AcrB transmembrane domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]