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Glycoside hydrolase/deacetylase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   7-stranded beta/alpha barrel [ 51988] (3)
Superfamily:   Glycoside hydrolase/deacetylase [ 88713] (8)
Families:   4-alpha-glucanotransferase, N-terminal domain [ 89554]
  alpha-mannosidase [ 88714] (2)
  AmyC N-terminal domain-like [ 102189] (2)
  NodB-like polysaccharide deacetylase [ 89559] (6)
  LamB/YcsF-like [ 117449] (3)
  PA1517-like [ 141965]
  Divergent polysaccharide deacetylase [ 141968]
  YdjC-like [ 159441]


Superfamily statistics
Genomes (2,953) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 16,760 102,490 25
Proteins 16,681 102,139 25


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)hydrolase activity0.57580.000000000000001615Least InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)metal ion binding0.0096310.1832Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding0.0000038290.00008994InformativeDirect
Molecular Function (MF)deacetylase activity0.0000000053330.00000000000003369Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.7805 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8544 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.07431 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000000000008356 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0001188 Moderately Informative Direct
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8667 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5814 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7294 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.5817 Moderately Informative Inherited
Biological Process (BP) pigment metabolic process 0.0004042 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0008152 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.3404 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.004487 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.002767 Informative Inherited
Biological Process (BP) immune effector process 0.003312 Informative Inherited
Biological Process (BP) growth 0.04515 Informative Inherited
Biological Process (BP) behavior 0.0403 Informative Inherited
Biological Process (BP) response to radiation 0.06464 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.001646 Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.0000003389 Highly Informative Direct
Biological Process (BP) pigmentation 0.00005533 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.001603 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.00425 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000000000000001615 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.01979 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.1832 Moderately Informative Inherited
Molecular Function (MF) magnesium ion binding 0.00008994 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0002254 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.00001482 Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.00000000000003369 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) vacuole 0.0004012 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000353 Moderately Informative Direct
Cellular Component (CC) Golgi apparatus 0.0003668 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0004892 Informative Direct
Cellular Component (CC) Golgi subcompartment 0.0006609 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In linear amides0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.002007Moderately InformativeInherited
Enzyme Commission (EC)Alpha-mannosidase0Highly InformativeDirect
Enzyme Commission (EC)Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase0.000000000006568Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processPolysaccharide degradation0.00000000002394InformativeDirect
Biological processLipid biosynthesis0.0000001221InformativeDirect
Biological processSporulation0.000003421InformativeDirect
Biological processNodulation0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Cellular componentGolgi apparatus0.0000001791Moderately InformativeDirect
Cellular componentSecreted0.02474Moderately InformativeInherited
Cellular componentLysosome0.0000002587InformativeDirect
Cellular componentCell wall0.0001016Highly InformativeDirect
DomainSignal0.0000000000003351Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.000000007655InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionZinc0.00009258Least InformativeDirect
Molecular functionCobalt0.000521InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycosidase0.0000000000004908InformativeDirect
Post-translational modificationGlycoprotein0.000000000426Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011330 SSF88713 Protein matches
Abstract

This entry represents a structural motif found in glycoside hydrolase families 38 (, e.g. alpha-mannosidase) [PubMed12960159] and 57 (, e.g. 4-alpha-glucanotransferase, N-terminal) [PubMed12618437], as well as in NodB-like polysaccharide deacetylase and in some hypothetical proteins (e.g. TT1467, N-terminal domain). This domain consists of a 7-stranded beta/alpha barrel, although in some families the beta-barrels may be distorted and may vary in the number of strands.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycoside hydrolase/deacetylase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Glycoside hydrolase/deacetylase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]