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PIN domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   PIN domain-like [ 88722]
Superfamily:   PIN domain-like [ 88723] (2)
Families:   PIN domain [ 89619] (7)
  5' to 3' exonuclease catalytic domain [ 53045] (4)


Superfamily statistics
Genomes (3,230) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 19,495 97,319 22
Proteins 19,473 97,239 22


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.67660Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.80670Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.91020.000000000002174Least InformativeInherited
Biological Process (BP)primary metabolic process10.000003231Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.67980Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.78840Least InformativeInherited
Biological Process (BP)biological regulation0.000000000066690.3134Least InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.93710.1273Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.043571Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.066111Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.015430.01874Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.050340.8548Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.11470.5141Moderately InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.000040150.0001948InformativeDirect
Biological Process (BP)regulation of growth00InformativeDirect
Biological Process (BP)regulation of cellular amide metabolic process0.000023720.001706InformativeInherited
Biological Process (BP)negative regulation of macromolecule biosynthetic process0.00059870.3543InformativeInherited
Biological Process (BP)negative regulation of gene expression0.0031690.00249InformativeInherited
Biological Process (BP)negative regulation of cellular biosynthetic process0.0009840.4054InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.0009840.01863InformativeInherited
Biological Process (BP)rRNA metabolic process0.000020130.000003137Highly InformativeDirect
Biological Process (BP)negative regulation of translation0.00000028620.00003286Highly InformativeDirect
Biological Process (BP)negative regulation of growth0.00000000000022640.00000000001204Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.66040Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.033690Moderately InformativeInherited
Molecular Function (MF)nuclease activity0.0000090140InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000000000002174 Least Informative Direct
Biological Process (BP) primary metabolic process 0.000003231 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.08653 Least Informative Inherited
Biological Process (BP) biological regulation 0.3134 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0002057 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0005338 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.01874 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2942 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.8548 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1273 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.5141 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1356 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.00000000000006985 Informative Direct
Biological Process (BP) response to radiation 0.0002158 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0001948 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00000000205 Informative Direct
Biological Process (BP) regulation of growth 0 Informative Direct
Biological Process (BP) ribosome biogenesis 0.0003557 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0000000217 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.001706 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.00249 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.3543 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.4054 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.01863 Informative Inherited
Biological Process (BP) ncRNA processing 0.001381 Informative Inherited
Biological Process (BP) DNA replication 0.000001264 Highly Informative Direct
Biological Process (BP) RNA catabolic process 0.0000000000002679 Highly Informative Direct
Biological Process (BP) response to UV 0.00000000007934 Highly Informative Direct
Biological Process (BP) rRNA metabolic process 0.000003137 Highly Informative Direct
Biological Process (BP) negative regulation of translation 0.00003286 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.00000000001204 Highly Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.000005472 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.003736 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.6944 Moderately Informative Inherited
Molecular Function (MF) nuclease activity 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.00008013 Informative Direct
Molecular Function (MF) DNA-directed DNA polymerase activity 0.000000001822 Highly Informative Direct
Molecular Function (MF) deoxyribonuclease activity 0.000001438 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.225 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7488 Least Informative Inherited
Cellular Component (CC) nuclear part 0.006505 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.01763 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processHost-virus interaction0.005036Moderately InformativeInherited
Biological processDNA repair0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus0.9814InformativeInherited
Biological processDecay of host mRNAs by virus0Highly InformativeDirect
Biological processDNA excision0.00000118Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentExosome0.0000004569Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.0000008734Moderately InformativeDirect
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PIN domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the PIN domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]