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Pyruvate oxidase and decarboxylase Pyr module family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thiamin diphosphate-binding fold (THDP-binding) [ 52517]
Superfamily:   Thiamin diphosphate-binding fold (THDP-binding) [ 52518] (8)
Family:   Pyruvate oxidase and decarboxylase Pyr module [ 88724] (8)


Family statistics
Genomes (2,644) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,764 42,452 22
Proteins 7,764 42,451 22


Gene Ontology (high-coverage)

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show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0006321 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000006485 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.861 Least Informative Inherited
Biological Process (BP) carboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000156 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00000002727 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0004009 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.003273 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.05554 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.5293 Moderately Informative Inherited
Biological Process (BP) cellular amino acid biosynthetic process 0.00000000002019 Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.01926 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.8269 Informative Inherited
Biological Process (BP) alpha-amino acid metabolic process 0.1101 Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.02919 Informative Inherited
Biological Process (BP) small molecule catabolic process 0.001975 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.008332 Informative Inherited
Biological Process (BP) lipid catabolic process 0.002267 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.2033 Informative Inherited
Biological Process (BP) aromatic compound catabolic process 0.02181 Informative Inherited
Biological Process (BP) pyruvate metabolic process 0.00001202 Highly Informative Direct
Biological Process (BP) aromatic amino acid family metabolic process 0.0003027 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular lipid catabolic process 0.001571 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid catabolic process 0.02721 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.009022 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.0982 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000006174 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00004168 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0.2102 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.1876 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) magnesium ion binding 0.000001339 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) cofactor binding 0.00000000004263 Informative Direct
Molecular Function (MF) vitamin binding 0.00000000001752 Highly Informative Direct
Molecular Function (MF) coenzyme binding 0.0000000000005405 Highly Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000000000005903 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.001865 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9634 Least Informative Inherited
Cellular Component (CC) microbody 0.00006457 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.2098Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.000005772Moderately InformativeDirect
Enzyme Commission (EC)Acetolactate synthase0.00000000008063Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.001021InformativeInherited
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionFlavoprotein5.658e-16Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionThiamine pyrophosphate0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLyase0.00000000003904Moderately InformativeDirect
Post-translational modificationDecarboxylase0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 45 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Thiamin diphosphate-binding fold (THDP-binding) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]