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Branched-chain alpha-keto acid dehydrogenase PP module family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thiamin diphosphate-binding fold (THDP-binding) [ 52517]
Superfamily:   Thiamin diphosphate-binding fold (THDP-binding) [ 52518] (8)
Family:   Branched-chain alpha-keto acid dehydrogenase PP module [ 88766] (4)


Family statistics
Genomes (2,183) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 4,434 21,879 20
Proteins 4,420 21,853 20


Gene Ontology (high-quality)

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show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.0000037660Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00022840.000006478Least InformativeDirect
Biological Process (BP)biosynthetic process0.014610.1856Least InformativeInherited
Biological Process (BP)carboxylic acid metabolic process0.000000019860Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.0000042430.0000000000003258Moderately InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.0000000000084970.00000000006164InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.0000000000067130InformativeDirect
Biological Process (BP)pyruvate metabolic process00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity0.0000000000058520Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors0.0000000070090Highly InformativeDirect
Cellular Component (CC)macromolecular complex0.00012720.000000002613Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.0079130Least InformativeInherited
Cellular Component (CC)catalytic complex0.0020020Moderately InformativeInherited
Cellular Component (CC)oxidoreductase complex0.0000000000025980InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000006478 Least Informative Direct
Biological Process (BP) biosynthetic process 0.1856 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) carboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000000003258 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.6344 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.4714 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.4269 Moderately Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.00000000006164 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0 Informative Direct
Biological Process (BP) small molecule catabolic process 0.3275 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.005284 Informative Inherited
Biological Process (BP) pyruvate metabolic process 0 Highly Informative Direct
Biological Process (BP) citrate metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.000007294 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Cellular Component (CC) macromolecular complex 0.000000002613 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00002622 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1549 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.00000000000000148 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0006998 Moderately Informative Direct
Cellular Component (CC) catalytic complex 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial matrix 0.00000000000002711 Informative Direct
Cellular Component (CC) oxidoreductase complex 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.9282Least InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.002014Moderately InformativeInherited
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0.0000002771Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processGlycolysis0Highly InformativeDirect
Biological processTricarboxylic acid cycle0Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionPotassium0.000006756InformativeDirect
Molecular functionPyruvate0Highly InformativeDirect
Molecular functionThiamine pyrophosphate0Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationLyase0.5902Moderately InformativeInherited
Post-translational modificationAcyltransferase0.0000319InformativeDirect
Post-translational modificationDecarboxylase0.000002186Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000000002442Least InformativeDirect
Post-translational modificationAcetylation0.0000000118Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 45 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Thiamin diphosphate-binding fold (THDP-binding) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]