SUPERFAMILY 1.75 HMM library and genome assignments server

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Protein kinases, catalytic subunit family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Family:   Protein kinases, catalytic subunit [ 88854] (63)


Family statistics
Genomes (1,856) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 125,827 372,019 219
Proteins 124,451 368,132 219


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0002171Least InformativeDirect
Disease Ontology (DO)gastrointestinal system cancer0.004771Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.0132Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.02787Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.07784Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1881Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.2076Moderately InformativeInherited
Disease Ontology (DO)retinal cell cancer0.000003616InformativeDirect
Disease Ontology (DO)malignant glioma0.00005245InformativeDirect
Disease Ontology (DO)large intestine cancer0.00006202InformativeDirect
Disease Ontology (DO)liver carcinoma0.0001792InformativeDirect
Disease Ontology (DO)lung carcinoma0.0002352InformativeDirect
Disease Ontology (DO)male reproductive organ cancer0.01553InformativeInherited
Disease Ontology (DO)parasitic infectious disease0.8646InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9474InformativeInherited
Disease Ontology (DO)synostosis0.0004391Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0004504Highly InformativeDirect
Disease Ontology (DO)parasitic helminthiasis infectious disease0.1026Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Incomplete penetrance0.0007419Moderately InformativeDirect
Mode of Inheritance (MI)Autosomal dominant inheritance0.000375Least InformativeDirect
Mode of Inheritance (MI)Somatic mutation0.000006182Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1086Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.0001409Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal heart morphology0.5764Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.008179InformativeInherited
Phenotypic Abnormality (PA)Atrial septal defect0.0001515Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.000001991Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.00001395Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.0001049Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0004434Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.07869Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.0000004534Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0001793Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.003593Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.03801Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.07778Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.166Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.8915Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.0000491InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development0.0001801InformativeDirect
Mammalian Phenotype (MP)abnormal heart layer morphology0.002627InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.05714InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.2348InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.4237InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.00006467Highly InformativeDirect
Mammalian Phenotype (MP)increased respiratory system tumor incidence0.0003191Highly InformativeDirect
Mammalian Phenotype (MP)sex reversal0.0003285Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.6633Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0.0004233Least InformativeDirect
Worm Phenotype (WP)cell development variant0.02131Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.07965Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2151Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.67Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.000001132Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.000001587Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.002733Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.05292Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.05646Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1193Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.1404Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.364Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.7205Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.7315Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.829Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.9343Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.9367Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.973Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.9852Moderately InformativeInherited
Worm Phenotype (WP)pericellular component development variant1Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant1Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.000008083InformativeDirect
Worm Phenotype (WP)metal response variant0.0001015InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0003922InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0005383InformativeDirect
Worm Phenotype (WP)chemosensory response variant0.001006InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.004677InformativeInherited
Worm Phenotype (WP)nervous system physiology variant0.009419InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.009446InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.01257InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.0325InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.04363InformativeInherited
Worm Phenotype (WP)egg laying variant0.07352InformativeInherited
Worm Phenotype (WP)chemical resistant0.09488InformativeInherited
Worm Phenotype (WP)cell component localization variant0.2203InformativeInherited
Worm Phenotype (WP)vulva development variant0.222InformativeInherited
Worm Phenotype (WP)drug resistant0.3004InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.3424InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.6939InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.7299InformativeInherited
Worm Phenotype (WP)cell number increased0.9131InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.9254InformativeInherited
Worm Phenotype (WP)chemical hypersensitive0.951InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant1InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)protein phosphorylation variant0.000000000001796Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.000000004479Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.000001173Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000001676Highly InformativeDirect
Worm Phenotype (WP)pericellular component physiology variant0.00002482Highly InformativeDirect
Worm Phenotype (WP)hypoxia response variant0.00003548Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.00003578Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.00004357Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.0001462Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0003246Highly InformativeDirect
Worm Phenotype (WP)neuron physiology variant0.0003671Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.002802Highly InformativeInherited
Worm Phenotype (WP)intestinal development variant0.06903Highly InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.075Highly InformativeInherited
Worm Phenotype (WP)aqueous positive chemotaxis variant0.0823Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.09933Highly InformativeInherited
Worm Phenotype (WP)negative chemotaxis variant0.7331Highly InformativeInherited
Worm Phenotype (WP)dye filling defect0.8641Highly InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0.9452Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

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YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0.2623Least InformativeInherited
Yeast Phenotype (YP)metabolism and growth0.4557Least InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.9501InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.000005507Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.000009263Highly InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0.000009695Highly InformativeDirect
Yeast Phenotype (YP)cell death0.0002214Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.01401Least InformativeInherited
Fly Phenotype (FP)visible0.00002087Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0.00003307Moderately InformativeDirect
Fly Phenotype (FP)size defective0.000000009037InformativeDirect
Fly Phenotype (FP)wild-type0.0000002628InformativeDirect
Fly Phenotype (FP)cell number defective0.0000005859InformativeDirect
Fly Phenotype (FP)cell death defective0.00002258InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.00002839InformativeDirect
Fly Phenotype (FP)planar polarity defective0.000238InformativeDirect
Fly Phenotype (FP)cell cycle defective0.0002555InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0008021InformativeDirect
Fly Phenotype (FP)sterile0.0008833InformativeDirect
Fly Phenotype (FP)increased occurrence of cell division0.00000849Highly InformativeDirect
Fly Phenotype (FP)cell migration defective0.0003316Highly InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.0007371Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0009293Least InformativeDirect
Fly Anatomy (FA)nervous system0.002278Least InformativeInherited
Fly Anatomy (FA)tagma0.003294Least InformativeInherited
Fly Anatomy (FA)anatomical group0.00884Least InformativeInherited
Fly Anatomy (FA)adult0.01049Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.01162Least InformativeInherited
Fly Anatomy (FA)larva0.04479Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2919Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.0002394Moderately InformativeDirect
Fly Anatomy (FA)female-specific anatomical entity0.001348Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.003458Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.004653Moderately InformativeInherited
Fly Anatomy (FA)gonad0.004871Moderately InformativeInherited
Fly Anatomy (FA)digestive system0.01242Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.01611Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.02684Moderately InformativeInherited
Fly Anatomy (FA)neuron0.0464Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05401Moderately InformativeInherited
Fly Anatomy (FA)adult head0.06083Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1246Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1729Moderately InformativeInherited
Fly Anatomy (FA)cell component0.00008051InformativeDirect
Fly Anatomy (FA)ovariole0.0004227InformativeDirect
Fly Anatomy (FA)imaginal disc0.0009565InformativeDirect
Fly Anatomy (FA)ommatidium0.01496InformativeInherited
Fly Anatomy (FA)midgut0.0307InformativeInherited
Fly Anatomy (FA)somatic stem cell0.1161InformativeInherited
Fly Anatomy (FA)sensory organ cell0.1578InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.1628InformativeInherited
Fly Anatomy (FA)photoreceptor cell0.3058InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.4644InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.4899InformativeInherited
Fly Anatomy (FA)epithelial tube0.6256InformativeInherited
Fly Anatomy (FA)somatic cell of ovariole0.0006687Highly InformativeDirect
Fly Anatomy (FA)pupa0.0009972Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.02651Highly InformativeInherited
Fly Anatomy (FA)inner photoreceptor cell0.4431Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.07969Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.0833Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1737Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.09693Moderately InformativeInherited
Zebrafish Anatomy (ZA)vasculature0.05516InformativeInherited
Zebrafish Anatomy (ZA)trunk0.1388InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.1958InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.5025InformativeInherited
Zebrafish Anatomy (ZA)axial vasculature0.0112Highly InformativeInherited
Zebrafish Anatomy (ZA)post-vent vasculature0.0887Highly InformativeInherited
Zebrafish Anatomy (ZA)trunk vasculature0.3164Highly InformativeInherited
Zebrafish Anatomy (ZA)integument0.3325Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.1123Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.3863Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.9897Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00001977InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0144InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.0001505Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.1511Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 299 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]