SUPERFAMILY 1.75 HMM library and genome assignments server

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DNA replication initiator (cdc21/cdc54) N-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   OB-fold [ 50198] (16)
Superfamily:   Nucleic acid-binding proteins [ 50249] (16)
Family:   DNA replication initiator (cdc21/cdc54) N-terminal domain [ 89332]


Family statistics
Genomes (128) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 134 873 1
Proteins 134 873 1


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.004735Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.02092Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.02155Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.02731Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.00002984Moderately InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0.0002667Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0.01606Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.06167Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.1858Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.3016Moderately InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.00002657InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.0001124InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.02549InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.0000000000000236Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.000002389Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality, incomplete penetrance0.0002448Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0004937Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.02739Least InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000001153Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.000001355Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0.00004171Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.00007101Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0003248Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.001104Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.001271Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.006541Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.0125Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01718Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.000000001891InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000000008509InformativeDirect
Worm Phenotype (WP)gonad development variant0.000003596InformativeDirect
Worm Phenotype (WP)drug hypersensitive0.00002789InformativeDirect
Worm Phenotype (WP)vulva morphology variant0.00007808InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0.002903InformativeInherited
Worm Phenotype (WP)chemical hypersensitive0.02115InformativeInherited
Worm Phenotype (WP)embryonic cell morphology variant0.00000000004169Highly InformativeDirect
Worm Phenotype (WP)nucleus defective early emb0.00000000006071Highly InformativeDirect
Worm Phenotype (WP)multiple nuclei0.00000002174Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.00000002679Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.00000005705Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.0000003445Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.0009797Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.007422Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)imaginal disc0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on ATP; involved in cellular and subcellular movement0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 186 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Nucleic acid-binding proteins domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]