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Neurotransmitter-gated ion-channel transmembrane pore family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Neurotransmitter-gated ion-channel transmembrane pore [ 90111]
Superfamily:   Neurotransmitter-gated ion-channel transmembrane pore [ 90112]
Family:   Neurotransmitter-gated ion-channel transmembrane pore [ 90113] (4)


Family statistics
Genomes (139) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,234 6,114 4
Proteins 2,225 6,048 4


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0007152Least InformativeDirect
Disease Ontology (DO)disease of mental health0.00000000000003496Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.3444Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease1Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.00000000000005221InformativeDirect
Disease Ontology (DO)schizophrenia0.00006591InformativeDirect
Disease Ontology (DO)epilepsy0.0409InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.09493InformativeInherited
Disease Ontology (DO)autistic disorder0.000000009235Highly InformativeDirect
Disease Ontology (DO)early myoclonic encephalopathy0.000004038Highly InformativeDirect
Disease Ontology (DO)Lewy body dementia0.00003542Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.00007329Highly InformativeDirect
Disease Ontology (DO)focal epilepsy0.071Highly InformativeInherited
Disease Ontology (DO)drug dependence0.1963Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0003299Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.02392Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.04469Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1146Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.2956Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5161Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.7608Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.9616Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9692Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.0181Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.04235Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.09592Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.09635Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1026Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.289Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3339Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.3739Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.4171Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.6342Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.7872Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.8015Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.8104Moderately InformativeInherited
Phenotypic Abnormality (PA)Fatigable weakness0.002437InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.01074InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.01359InformativeInherited
Phenotypic Abnormality (PA)Reduced consciousness/confusion0.016InformativeInherited
Phenotypic Abnormality (PA)Encephalopathy0.04714InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.06875InformativeInherited
Phenotypic Abnormality (PA)Impairment in personality functioning0.08346InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.0942InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1225InformativeInherited
Phenotypic Abnormality (PA)Scoliosis0.1353InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.1606InformativeInherited
Phenotypic Abnormality (PA)Seizures0.1825InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.1941InformativeInherited
Phenotypic Abnormality (PA)Abnormal involuntary eye movements0.9568InformativeInherited
Phenotypic Abnormality (PA)Decreased miniature endplate potentials0.0000001007Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness of neck muscles0.0000001007Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals0.0000001603Highly InformativeDirect
Phenotypic Abnormality (PA)Multiple pterygia0.0000002511Highly InformativeDirect
Phenotypic Abnormality (PA)Amyoplasia0.0000002511Highly InformativeDirect
Phenotypic Abnormality (PA)Thoracic kyphoscoliosis0.00000036Highly InformativeDirect
Phenotypic Abnormality (PA)Ankle weakness0.0000004733Highly InformativeDirect
Phenotypic Abnormality (PA)Uncontrolled eye movements0.0000006888Highly InformativeDirect
Phenotypic Abnormality (PA)Weakness of long finger extensor muscles0.0000007163Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cervical curvature0.0000008106Highly InformativeDirect
Phenotypic Abnormality (PA)Weakness of the intrinsic hand muscles0.0000009727Highly InformativeDirect
Phenotypic Abnormality (PA)Jerky head movements0.000002173Highly InformativeDirect
Phenotypic Abnormality (PA)Malignant hyperthermia0.00003837Highly InformativeDirect
Phenotypic Abnormality (PA)Punding0.00005413Highly InformativeDirect
Phenotypic Abnormality (PA)Low self esteem0.00006478Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness of respiratory muscles0.0001168Highly InformativeDirect
Phenotypic Abnormality (PA)Reduced vital capacity0.0001311Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.0002532Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic heart0.0003097Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.0003939Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of binocular vision0.0004547Highly InformativeDirect
Phenotypic Abnormality (PA)Epileptic encephalopathy0.0005222Highly InformativeDirect
Phenotypic Abnormality (PA)Febrile seizures0.0006668Highly InformativeDirect
Phenotypic Abnormality (PA)Cystic hygroma0.000706Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.0007095Highly InformativeDirect
Phenotypic Abnormality (PA)Myoclonus0.0007255Highly InformativeDirect
Phenotypic Abnormality (PA)Drowsiness0.000745Highly InformativeDirect
Phenotypic Abnormality (PA)Nonconvulsive status epilepticus0.0008294Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability0.0008548Highly InformativeDirect
Phenotypic Abnormality (PA)Proximal muscle weakness0.001039Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the shoulder girdle musculature0.00104Highly InformativeInherited
Phenotypic Abnormality (PA)Limb muscle weakness0.001947Highly InformativeInherited
Phenotypic Abnormality (PA)EMG abnormality0.02066Highly InformativeInherited
Phenotypic Abnormality (PA)Specific learning disability0.02092Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of facial musculature0.03189Highly InformativeInherited
Phenotypic Abnormality (PA)Generalized-onset seizure0.08927Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.09447Highly InformativeInherited
Phenotypic Abnormality (PA)Dyspnea0.3518Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0000000004018Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.000001145Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.00968Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.04856Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.4605Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.7588Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.8067Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000000000889InformativeDirect
Mammalian Phenotype (MP)abnormal sensory capabilities/reflexes/nociception0.0007293InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.0007404InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0007879InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.0008502InformativeDirect
Mammalian Phenotype (MP)seizures0.001002InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.01833InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.07718InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2734InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.2828InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.6718InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7579InformativeInherited
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents0.000000002248Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.000003819Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.000008394Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.00001153Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.0001166Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.000118Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0002072Highly InformativeDirect
Mammalian Phenotype (MP)narrow eye opening0.000326Highly InformativeDirect
Mammalian Phenotype (MP)decreased fear-related response0.0006807Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.009185Highly InformativeInherited
Mammalian Phenotype (MP)renal/urinary system inflammation0.01068Highly InformativeInherited
Mammalian Phenotype (MP)abnormal anterior uvea morphology0.01133Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.02121Highly InformativeInherited
Mammalian Phenotype (MP)abnormal involuntary movement0.02867Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory ganglion morphology0.03678Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.2189Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cranial ganglia morphology0.2339Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hearing electrophysiology0.529Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0000000008748Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0000000008748Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.003737Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.0000000001144Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00000008044Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.000004785Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.007972Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.007972Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.008059Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.008148Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.00957Moderately InformativeInherited
Worm Phenotype (WP)endocytic transport defect0InformativeDirect
Worm Phenotype (WP)head movement variant0.000000000000009339InformativeDirect
Worm Phenotype (WP)body posture variant0.00000000000003231InformativeDirect
Worm Phenotype (WP)body bend variant0.00000000000005896InformativeDirect
Worm Phenotype (WP)tail bend angle variant0.000000000002157InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.00000000007287InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00000001566InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.000002221InformativeDirect
Worm Phenotype (WP)directionality variant0.01814InformativeInherited
Worm Phenotype (WP)locomotion reduced0.09321InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.2215InformativeInherited
Worm Phenotype (WP)metal response variant0.3052InformativeInherited
Worm Phenotype (WP)small0.8631InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.0000001012Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0000005289Highly InformativeDirect
Worm Phenotype (WP)fat0.000004475Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.00001028Highly InformativeDirect
Worm Phenotype (WP)short0.00002024Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.00004441Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001211Highly InformativeDirect
Worm Phenotype (WP)hypoosmotic shock hypersensitive0.0001681Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0007484Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis variant0.1719Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)circadian rhythm defective0.0009387InformativeDirect
Fly Phenotype (FP)chemical resistant0.000001314Highly InformativeDirect
Fly Phenotype (FP)phototaxis defective0.00008212Highly InformativeDirect
Fly Phenotype (FP)temperature response defective0.0009786Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.04886Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.6857Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3162Moderately InformativeInherited
Zebrafish Anatomy (ZA)spinal cord0.0005648Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.00005043Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)tailbud stage0.1498InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 35 and 360.000007541Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Neurotransmitter-gated ion-channel transmembrane pore domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]