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Neurotransmitter-gated ion-channel transmembrane pore family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Neurotransmitter-gated ion-channel transmembrane pore [ 90111]
Superfamily:   Neurotransmitter-gated ion-channel transmembrane pore [ 90112]
Family:   Neurotransmitter-gated ion-channel transmembrane pore [ 90113] (4)


Family statistics
Genomes (139) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,234 6,114 4
Proteins 2,225 6,048 4


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0007152Least InformativeDirect
Disease Ontology (DO)disease of mental health0.00000000000003496Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.3444Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease1Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.00000000000005221InformativeDirect
Disease Ontology (DO)schizophrenia0.00006591InformativeDirect
Disease Ontology (DO)epilepsy0.0409InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.09493InformativeInherited
Disease Ontology (DO)autistic disorder0.000000009235Highly InformativeDirect
Disease Ontology (DO)early myoclonic encephalopathy0.000004038Highly InformativeDirect
Disease Ontology (DO)Lewy body dementia0.00003542Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.00007329Highly InformativeDirect
Disease Ontology (DO)focal epilepsy0.071Highly InformativeInherited
Disease Ontology (DO)drug dependence0.1963Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.000314Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.02536Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.04798Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1189Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.3126Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5279Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.6301Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.9658Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9663Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.01985Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.04583Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.09937Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1044Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.2039Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.2386Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.2856Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.345Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.3788Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.6311Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.6447Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.8113Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.002942InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.01208InformativeInherited
Phenotypic Abnormality (PA)Encephalopathy0.01443InformativeInherited
Phenotypic Abnormality (PA)Reduced consciousness/confusion0.0151InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.07247InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.07915InformativeInherited
Phenotypic Abnormality (PA)Impairment in personality functioning0.08681InformativeInherited
Phenotypic Abnormality (PA)Scoliosis0.1386InformativeInherited
Phenotypic Abnormality (PA)Seizures0.1912InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.1945InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1957InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.3121InformativeInherited
Phenotypic Abnormality (PA)Abnormal involuntary eye movements0.9589InformativeInherited
Phenotypic Abnormality (PA)Abnormal synaptic transmission at the neuromuscular junction1InformativeInherited
Phenotypic Abnormality (PA)Decreased miniature endplate potentials0.00000009589Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness of neck muscles0.00000009589Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals0.0000001524Highly InformativeDirect
Phenotypic Abnormality (PA)Multiple pterygia0.000000242Highly InformativeDirect
Phenotypic Abnormality (PA)Amyoplasia0.000000242Highly InformativeDirect
Phenotypic Abnormality (PA)Thoracic kyphoscoliosis0.0000003435Highly InformativeDirect
Phenotypic Abnormality (PA)Uncontrolled eye movements0.0000006352Highly InformativeDirect
Phenotypic Abnormality (PA)Weakness of long finger extensor muscles0.0000006847Highly InformativeDirect
Phenotypic Abnormality (PA)Weakness of the intrinsic hand muscles0.0000009289Highly InformativeDirect
Phenotypic Abnormality (PA)Ankle weakness0.000001423Highly InformativeDirect
Phenotypic Abnormality (PA)Jerky head movements0.0000021Highly InformativeDirect
Phenotypic Abnormality (PA)Malignant hyperthermia0.00003692Highly InformativeDirect
Phenotypic Abnormality (PA)Punding0.00004123Highly InformativeDirect
Phenotypic Abnormality (PA)Epileptic encephalopathy0.00004712Highly InformativeDirect
Phenotypic Abnormality (PA)Low self esteem0.00005799Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.00008617Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness of respiratory muscles0.0001118Highly InformativeDirect
Phenotypic Abnormality (PA)Reduced vital capacity0.0001163Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic heart0.0002994Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.000719Highly InformativeDirect
Phenotypic Abnormality (PA)Cystic hygroma0.0007291Highly InformativeDirect
Phenotypic Abnormality (PA)Drowsiness0.0007364Highly InformativeDirect
Phenotypic Abnormality (PA)Myoclonus0.0007605Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability0.0007934Highly InformativeDirect
Phenotypic Abnormality (PA)Febrile seizures0.0008017Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.0009928Highly InformativeDirect
Phenotypic Abnormality (PA)Proximal muscle weakness0.004175Highly InformativeInherited
Phenotypic Abnormality (PA)Limb muscle weakness0.006461Highly InformativeInherited
Phenotypic Abnormality (PA)EMG abnormality0.01998Highly InformativeInherited
Phenotypic Abnormality (PA)Specific learning disability0.02068Highly InformativeInherited
Phenotypic Abnormality (PA)EEG with spike-wave complexes0.05233Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of facial musculature0.05675Highly InformativeInherited
Phenotypic Abnormality (PA)Generalized-onset seizure0.09328Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.09508Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cervical spine0.1148Highly InformativeInherited
Phenotypic Abnormality (PA)Dyspnea0.3682Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0000000004052Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.000001144Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.009679Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.04873Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.4614Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.7588Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.8073Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.0000000008843InformativeDirect
Mammalian Phenotype (MP)abnormal sensory capabilities/reflexes/nociception0.000727InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.00074InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0007874InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.0008485InformativeDirect
Mammalian Phenotype (MP)seizures0.0009993InformativeDirect
Mammalian Phenotype (MP)abnormal eye physiology0.01834InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.07716InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2735InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.2827InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.6718InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.758InformativeInherited
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents0.000000002249Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.000003814Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.000008388Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.00001152Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.0001166Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.000118Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0002074Highly InformativeDirect
Mammalian Phenotype (MP)narrow eye opening0.000326Highly InformativeDirect
Mammalian Phenotype (MP)decreased fear-related response0.0006809Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.009122Highly InformativeInherited
Mammalian Phenotype (MP)renal/urinary system inflammation0.01068Highly InformativeInherited
Mammalian Phenotype (MP)abnormal anterior uvea morphology0.01134Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.02122Highly InformativeInherited
Mammalian Phenotype (MP)abnormal involuntary movement0.02869Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory ganglion morphology0.03725Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.219Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cranial ganglia morphology0.2335Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hearing electrophysiology0.5291Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.000000001567Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00000000174Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0002073Least InformativeDirect
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.000000001038Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.000002286Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0006706Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0007032Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant1Moderately InformativeInherited
Worm Phenotype (WP)endocytic transport defect0InformativeDirect
Worm Phenotype (WP)head movement variant0.00000000000001062InformativeDirect
Worm Phenotype (WP)body posture variant0.0000000000005556InformativeDirect
Worm Phenotype (WP)tail bend angle variant0.000000000002423InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0000000001705InformativeDirect
Worm Phenotype (WP)chemical resistant0.0000000007088InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.000000001664InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00000055InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0000008795InformativeDirect
Worm Phenotype (WP)chemosensory response variant0.00000453InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000136InformativeDirect
Worm Phenotype (WP)organism temperature response variant0.01295InformativeInherited
Worm Phenotype (WP)metal response variant0.23InformativeInherited
Worm Phenotype (WP)locomotion reduced0.2922InformativeInherited
Worm Phenotype (WP)small0.8677InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)coelomocyte endocytosis defective0Highly InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.0000000004681Highly InformativeDirect
Worm Phenotype (WP)synaptic transmission variant0.000001479Highly InformativeDirect
Worm Phenotype (WP)fat0.000004236Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.00000828Highly InformativeDirect
Worm Phenotype (WP)short0.00002338Highly InformativeDirect
Worm Phenotype (WP)thermotaxis variant0.00003963Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.00006375Highly InformativeDirect
Worm Phenotype (WP)hypoosmotic shock hypersensitive0.0001687Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0004906Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0006393Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.0419Highly InformativeInherited
Worm Phenotype (WP)aqueous positive chemotaxis variant1Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)chemical resistant0.000001412Highly InformativeDirect
Fly Phenotype (FP)phototaxis defective0.00008247Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.00005398Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)tailbud stage0.151InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 35 and 360.000009055Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Neurotransmitter-gated ion-channel transmembrane pore domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]