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Troponin coil-coiled subunits superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Troponin coil-coiled subunits [ 90250] (2)
Families:   Troponin T [ 90251]
  Troponin I [ 90254]


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,389 4,154 7
Proteins 1,374 4,090 7


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.008727Moderately InformativeInherited
Disease Ontology (DO)intrinsic cardiomyopathy0.00001884InformativeDirect
Disease Ontology (DO)myocardial infarction0.0001901InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.473Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.09827Moderately InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1061InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the upper limbs0.000986Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle morphology0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0002455Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.002853Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004371Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01172Least InformativeInherited
Worm Phenotype (WP)drug response variant0.0003097Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.002185Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.002222Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.3718Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.7135Moderately InformativeInherited
Worm Phenotype (WP)male mating variant0.00000002431InformativeDirect
Worm Phenotype (WP)nicotine response variant0.00000006223InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0003215InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0007066InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0007423InformativeDirect
Worm Phenotype (WP)defecation variant0.006556InformativeInherited
Worm Phenotype (WP)egg laying variant0.08345InformativeInherited
Worm Phenotype (WP)pericellular component physiology variant0.00000137Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.0000142Highly InformativeDirect
Worm Phenotype (WP)body vacuole0.00001713Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0002219Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0004845Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.00201Highly InformativeInherited
Worm Phenotype (WP)post hermaphrodite contact variant0.01094Highly InformativeInherited
Worm Phenotype (WP)neurite development variant0.1001Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.2467Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.08884Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.0009699Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0.06189Moderately InformativeInherited
Zebrafish Anatomy (ZA)musculature system0.00002521InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.3259Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0.7728Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0004576InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.001553InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Troponin coil-coiled subunits domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Troponin coil-coiled subunits superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]