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Troponin coil-coiled subunits superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Troponin coil-coiled subunits [ 90250] (2)
Families:   Troponin T [ 90251]
  Troponin I [ 90254]


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,389 4,154 7
Proteins 1,374 4,090 7


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.008727Moderately InformativeInherited
Disease Ontology (DO)intrinsic cardiomyopathy0.00001884InformativeDirect
Disease Ontology (DO)myocardial infarction0.0001901InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4732Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.09845Moderately InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1059InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the upper limbs0.0009857Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle morphology0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0002526Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.002886Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004602Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01639Least InformativeInherited
Worm Phenotype (WP)drug response variant0.0004326Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.001063Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.002236Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.002274Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.4972Moderately InformativeInherited
Worm Phenotype (WP)male mating variant0.0000000252InformativeDirect
Worm Phenotype (WP)nicotine response variant0.00000006294InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0003242InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0007223InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0007527InformativeDirect
Worm Phenotype (WP)defecation variant0.009462InformativeInherited
Worm Phenotype (WP)egg laying variant0.1255InformativeInherited
Worm Phenotype (WP)pericellular component physiology variant0.000001956Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.00001545Highly InformativeDirect
Worm Phenotype (WP)body vacuole0.00001726Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0002236Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0004966Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.002042Highly InformativeInherited
Worm Phenotype (WP)post hermaphrodite contact variant0.01076Highly InformativeInherited
Worm Phenotype (WP)neurite development variant0.09757Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.2425Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.09166Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.06182Moderately InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.0000006252InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.3251Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0.773Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0004583InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.001556InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Troponin coil-coiled subunits domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Troponin coil-coiled subunits superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]