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Myosin rod fragments superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Myosin rod fragments [ 90257]
Families:   Myosin rod fragments [ 90258] (2)


Superfamily statistics
Genomes (685) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,319 34,780 6
Proteins 4,103 15,049 4


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)intrinsic cardiomyopathy0.002903InformativeInherited
Disease Ontology (DO)dilated cardiomyopathy0.0006927Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.01816Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1202Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1647Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.2203Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.3446Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6957Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.00953Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.02973Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.1254Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1712Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1843Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.4559Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.001235InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the shoulder girdle musculature0.001482InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.01035InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.01948InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.02279InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.02576InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.1722InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.3631InformativeInherited
Phenotypic Abnormality (PA)Scapular winging0.0003572Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0005851Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal left ventricle morphology0.0006799Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebral ischemia0.000969Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricular function0.000988Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02636Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3912Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7306Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0003942InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.113InformativeInherited
Mammalian Phenotype (MP)cardiac interstitial fibrosis0.0001677Highly InformativeDirect
Mammalian Phenotype (MP)cardiac hypertrophy0.0005145Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.03783Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.04097Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.08324Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.09645Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.1084Least InformativeInherited
Worm Phenotype (WP)endocytic transport variant0.0004442Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.01772Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.2057Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00002306InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001148InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000407InformativeDirect
Worm Phenotype (WP)drug resistant0.0007073InformativeDirect
Worm Phenotype (WP)locomotion reduced0.001221InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.00000007375Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00003688Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.096Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.0584Moderately InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.0001345InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.35Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.6194Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.05697Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.01848InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.005558Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000008977Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000000001292InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin rod fragments domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Myosin rod fragments superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]