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Myosin rod fragments superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Myosin rod fragments [ 90257]
Families:   Myosin rod fragments [ 90258] (2)


Superfamily statistics
Genomes (685) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,319 34,780 6
Proteins 4,103 15,049 4


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)intrinsic cardiomyopathy0.002903InformativeInherited
Disease Ontology (DO)dilated cardiomyopathy0.0006927Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.01534Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1111Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.2227Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.3241Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3269Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.00946Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.08555Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1614Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.001348InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.01878InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.02546InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.03402InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.1604InformativeInherited
Phenotypic Abnormality (PA)Left ventricular dysfunction0.00009953Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.0003391Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0006096Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02629Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3912Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7302Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0003943InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1134InformativeInherited
Mammalian Phenotype (MP)cardiac interstitial fibrosis0.0001678Highly InformativeDirect
Mammalian Phenotype (MP)cardiac hypertrophy0.000515Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.03304Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.03869Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.04609Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.09016Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.09595Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0961Least InformativeInherited
Worm Phenotype (WP)movement variant0.01569Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.3209Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00002081InformativeDirect
Worm Phenotype (WP)drug resistant0.000625InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0008265InformativeDirect
Worm Phenotype (WP)locomotion reduced0.001092InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.00000006709Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00003411Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.09594Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.05961Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.1484Moderately InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.0001243InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.3475Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.619Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.05723Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.01897InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.005536Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000008791Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000000001252InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin rod fragments domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Myosin rod fragments superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]