SUPERFAMILY 1.75 HMM library and genome assignments server

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Myosin rod fragments family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Myosin rod fragments [ 90257]
Family:   Myosin rod fragments [ 90258] (2)


Family statistics
Genomes (95) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 869 2,086 3
Proteins 857 2,057 3


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)heart disease0.09028InformativeInherited
Disease Ontology (DO)dilated cardiomyopathy0.0003588Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.0111Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.09367Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1431Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.179Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2095Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.652Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7302Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.006395Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.01694Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.01799Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.01987Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1043Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.1418Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.166Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.4755Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hip joint0.001516InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.007817InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.01711InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.01982InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.02549InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.02668InformativeInherited
Phenotypic Abnormality (PA)Abnormal adipose tissue morphology0.05109InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.05202InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.06189InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.1468InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.3128InformativeInherited
Phenotypic Abnormality (PA)Left ventricular dysfunction0.00007058Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.0002363Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal left ventricle morphology0.0002689Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0004308Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebral ischemia0.0007863Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of peripheral nervous system electrophysiology0.0008193Highly InformativeDirect
Phenotypic Abnormality (PA)Lipodystrophy0.0008926Highly InformativeDirect
Phenotypic Abnormality (PA)Limb muscle weakness0.04598Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0221Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3494Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.6997Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0002849InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle wall thickness0.0002903InformativeDirect
Mammalian Phenotype (MP)abnormal heart size0.09202InformativeInherited
Mammalian Phenotype (MP)enlarged heart0.0119Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.1501Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.1787Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.001785Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.02097Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.03237Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00003936InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001143InformativeDirect
Worm Phenotype (WP)hermaphrodite physiology variant0.0002607InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0007338InformativeDirect
Worm Phenotype (WP)locomotion reduced0.002161InformativeInherited
Worm Phenotype (WP)sluggish0.00005749Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.0001682Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.08191Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.04606Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.1301Moderately InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.00008176InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.2108Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.3752Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.03917Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.01756InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Myosin rod fragments domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]