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For a list of input domains (e.g., a list of unusual domains found in a genome as compared to another genome) and the target ontologies (e.g., GO), the dcGO Enrichment uses domain-centric annotations and conducts enrichment analysis to identify the ontological terms enriched.

• Enrichment analysis is based on the hypergeometric distribution, followed by FDR-based assessment of the statistical significance of term enrichments.
• The dcGO Enrichment takes all annotatable domains (with respects to ontology) as the test background.
• The user can sumbit a list of domains containing single group (one entry per line) or multiple groups (1st column for group id; 2nd for SCOP domain id).
• Both of SCOP domains and PFAM domains are supported:
  • When using SCOP domains, the domain id can be either SCOP unique identifiers (sunid), or SCOP concise classification strings (sccs), or mixture of them.
  • When using PFAM domains, only Gene Ontology (GO) is supported.

• e.g., performing enrichment analysis for a list of SCOP domains '46689,47266,55550,56854,109604':
  http://supfam.org/SUPERFAMILY/cgi-bin/dcenrichment.cgi?domain_query=46689,47266,55550,56854,109604;domain_type=SCOP_sf
• e.g., performing enrichment analysis for a list of PFAM domains 'PF05110,PF01833,PF01614,PF04082,PF00651':
  http://supfam.org/SUPERFAMILY/cgi-bin/dcenrichment.cgi?domain_query=PF05110,PF01833,PF01614,PF04082,PF00651;domain_type=pfam