ENSNLEP00000020496 from Nomascus leucogenys 76

For a sequence (see Protein sequence) in target, dcGO predictor has the following procedures to predict the ontology terms of the target:

First, obtain Domain architecture and its residual domains and supra-domains from the SUPERFAMILY database.

Then, use the domain-centric annotations to predict the ontology terms of the target:

If a target contained a domain/supra-domain, then all ontology terms associated to that domain/supra-domain are transferred to the target (together with hypergeometric score, h-score);
When a target-to-term transfer is supported by one or more residential domains/supra-domains, sum up h-scores to calculate predictive score (p-score);
The p-score is then rescaled to the range of 0-1. For each namespace (e.g., three sub-ontologies for GO), p-score=(SUM-MIN)/(MAX-MIN), where SUM is the sum of all h-scores to support a term transferred to the target, MIN and MAX are respectively the minimum and maximum of SUM over a whole list of predicted terms for the target;

Finally, the predictive score being rescaled is used to rank the predictions. The higher value of the p-score indicates the more evident the prediction is. In the dcGO, each ontology has a slim version on its own, containing ontological terms at four levels of increasing granularity (that is, being highly general, general, specific, and highly specific). Listed in the table are the top 5 predictions for each specificity and for each namespace. In addition to those restricted by the term specificity, i.e., Export prediction (slim version), the full list of predictions are also provided for the download, i.e., Export prediction (full version).

MGAMTQLLAGVFLAFLALTTEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPV GSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVK ELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGW KGPNCSEPECPGNCHLRGQCIDGQCICDEGFTGEDCSQLACPRDCNDQGKCVNGVCICFE GYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECV CDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKLTCPHACHDQGRCEEGQ CVCDEGFAGVDCSEKRCPADCHNHGRCVDGQCECDDGFTGADCGELKCPNGCSGRGRCVN GQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRC VNGMCVCDDGYTGEDCRDRQCPRDCSNRGRCVDGQCVCEDGFTGPDCAELSCPNDCHGRG RCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGHCVDGQCICHEGFTGLDCGQRSCPNDCSN LGQCVSGRCICNEGYTGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTH EGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKF KSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYE ISLHIVKNNTRGPGLKRVTTTRLDAPSQVEVKDVTDTTALITWFKPLAEIDGIELTYGIK DVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLR RVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTE YGIGVSAVKEDKESNPATINAATELDTPKALHVSETAETSLTLLWKTPLAKFDRYRLNYS LPTGQWVGVQLPRNTTSYVLRGLEPGQEYSVLLTAEKGRHKSKPAHVKASTEQAPELENL TVTEAGWDGLRLNWTAADQAYEHFVIQVQEANKVEAAQNLTVPGSLRAVDIPGLKAATPY TVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQ EADTVEAAQNLTVPGTLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMG NLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEAEQVEEAHNLTVPGSLRSVEISGLRAGT PYTITLHSEVRGHSTRPLAVEVTTEELPQLGDLALSQVGWDGLRLNWTAADNAYEHFVIQ VQEVNKVEAAQNLTVHGSLRAMDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPE IGNLNVSDITPESFNLSWTATDGIFEIFTIEIIDSNRLLETVEYNISGAERTAHISGLPP STDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFL VTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAE PEVDNLLVSDATPDGFRLSWTADEGVFDDFVLKIRDTKKQSEPLEITLLAPERTRDITGL REATEYEIELYGISKGRRSQPVSTIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESF RITYVPITGGIPSMVTVDGTKTQTRLVKLIPGVEYLVNIIAMKGFEESEPVSGSFTTALD GPSGLVTSNITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPV TEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLV YESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPF PKDCSQAMLNGDTTSGLYTIYLNGDKAQALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW KAYAAGFGDRREEFWLGNASLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYK LKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGD NNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA

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ENSNLEP00000020496 (Nomascus leucogenys 76_1.0)

Protein sequence

Domain architecture