SUPERFAMILY 1.75 HMM library and genome assignments server

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MoaD-related protein, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   TBP-like [ 55944] (11)
Superfamily:   MoaD-related protein, C-terminal domain [ 103239]
Families:   MoaD-related protein, C-terminal domain [ 103240]

Superfamily statistics
Genomes (9) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 9 35 1
Proteins 9 35 1

Functional annotation
General category Other
Detailed category Unknown function

Function annotation of SCOP domain superfamilies

InterPro annotation
Cross references IPR015272 SSF103239 Protein matches

In Escherichia coli, the MoaD protein plays a central role in the conversion of precursor Z to molybdopterin (MPT) during molybdenum cofactor biosynthesis. MoaD has a fold similar to that of ubiquitin and contains a highly conserved C-terminal Gly-Gly motif, which in its active form contains a transferrable sulphur in the form of a thiocarboxylate group [PubMed17223713].

This entry represents a domain found in MoaD-related proteins, but with a different structure from the MoaD domain; this domain consists of a TBP-like fold of beta/apha/beta(4)/alpha. These proteins are found in Thermus thermophilus and contain a ubiquitin-like MoaD domain at their N-terminal, and the domain represented by this entry at their C-terminal. One of these proteins is threonine synthase , which catalyses the conversion of O-phospho-L-homoserine to L-threonine and phosphate.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a MoaD-related protein, C-terminal domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the MoaD-related protein, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]