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|General category ||Regulation|
|Detailed category ||DNA-binding|
Document: Function annotation of SCOP domain superfamilies
|Cross references ||IPR006699 SSF110391 Protein matches|
Glycerol enters bacterial cells via facilitated diffusion, an
energy-independent transport process catalysed by the glycerol transport
facilitator GlpF, an integral membrane
protein of the aquaporin family. Intracellular
glycerol is usually converted to glycerol-3-P in an ATP-requiring
phosphorylation reaction catalysed by glycerol kinase (GlpK).
Glycerol-3-P, the inducer of the glpFK operon, is not a substrate for GlpF
and hence remains entrapped in the cell where it is metabolized further. In
some bacterial species, for example Bacillus subtilis, glycerol-3-P activates the antiterminator GlpP . In Bacillus subtilis, glpF and glpK are organised in an operon followed by the
glycerol-3-P dehydrogenase-encoding glpD gene and preceded by glpP
coding for an antiterminator regulating the expression of glpFK, glpD and
glpTQ. Their induction
requires the inducer glycerol-3-P, which activates the antiterminator GlpP
by allowing it to bind to the leader region
of glpD and presumably also of glpFK and glpTQ
PDBeMotif information about ligands, sequence and structure motifs
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
Alignments of sequences to 1 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
Browse and view proteins in genomes which have
different domain combinations including a GlpP-like domain.
Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
There are 1 hidden Markov models representing the GlpP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]