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Iron-dependent repressor protein, dimerization domain superfamily
|General category ||Regulation|
|Detailed category ||DNA-binding|
Document: Function annotation of SCOP domain superfamilies
|Cross references ||IPR001367 SSF47979 Protein matches|
|Abstract ||The diphtheria toxin repressor protein (DTXR) is a member of this group . In
Corynebacterium diphtheriae where it has been studied in some detail this protein acts
as an iron-binding repressor of dipheteria toxin gene expression and may serve as a
global regulator of gene expression. The N-terminus may be involved in iron binding and
may associate with the Tox operator. Binding of DTXR to Tox operator requires a divalent
metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak
PDBeMotif information about ligands, sequence and structure motifs
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Internal database links
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
Alignments of sequences to 3 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
Browse and view proteins in genomes which have
different domain combinations including a Iron-dependent repressor protein, dimerization domain domain.
Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
There are 3 hidden Markov models representing the Iron-dependent repressor protein, dimerization domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]