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Cell cycle regulatory proteins superfamily
|General category ||Processes_IC|
|Detailed category ||Cell cycle, Apoptosis|
Document: Function annotation of SCOP domain superfamilies
|Cross references ||IPR000789 SSF55637 Protein matches|
In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle
progression, and are required for the G1 and G2 stages of cell division . The
proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS),
which is essential for their function. This regulatory subunit is a small protein of 79 to 150
residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known,
while mammals have two highly related isoforms. The regulatory subunits exist as hexamers,
formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual
12-stranded beta-barrel structure . Through the barrel centre runs a 12A diameter
tunnel, lined by 6 exposed helix pairs . Six kinase units can be modelled to bind the
hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase
multimerisation [8491379, 8211159].
PDBeMotif information about ligands, sequence and structure motifs
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Internal database links
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
Alignments of sequences to 5 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
Browse and view proteins in genomes which have
different domain combinations including a Cell cycle regulatory proteins domain.
Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
There are 5 hidden Markov models representing the Cell cycle regulatory proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]