SUPERFAMILY 1.75 HMM library and genome assignments server

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Monooxygenase (hydroxylase) regulatory protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Monooxygenase (hydroxylase) regulatory protein [ 56028]
Superfamily:   Monooxygenase (hydroxylase) regulatory protein [ 56029]
Families:   Monooxygenase (hydroxylase) regulatory protein [ 56030] (3)

Superfamily statistics
Genomes (95) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 142 1,197 5
Proteins 142 1,197 5

Functional annotation
General category Metabolism
Detailed category Redox

Function annotation of SCOP domain superfamilies

InterPro annotation
Cross references IPR003454 SSF56029 Protein matches
Abstract This family consists of monooxygenase components such as MmoB methane monooxygenase regulatory protein B. When MmoB is present at low concentration it converts methane monooxygenase from an oxidase to a hydroxylase and stabilizes intermediates required for the activation of dioxygen [PubMed10393915]. Also found in this family is DmpM or Phenol hydroxylase protein component P2, this protein lacks redox co-factors and is required for optimal turnover of Phenol hydroxylase [PubMed9012665]. Phenol hydroxylase catabolises phenol and some of its methylated derivatives in the first step of phenol biodegradation, and is required for growth on phenol. The multicomponent enzyme is made up of P0, P1, P2, P3, P4 and P5 polypeptides.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Monooxygenase (hydroxylase) regulatory protein domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Monooxygenase (hydroxylase) regulatory protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]