Family Assignments

Domains Proteins SCOP Link Families
30 30 SCOP 88854 Protein kinases, catalytic subunit
25 20 SCOP 49550 Multidomain cupredoxins
21 21 SCOP 48265 Cytochrome P450
20 20 SCOP 52592 G proteins
19 19 SCOP 51396 FMN-linked oxidoreductases
12 12 SCOP 51431 Aldo-keto reductases (NADP)
12 12 SCOP 81268 Tandem AAA-ATPase domain
12 11 SCOP 81269 Extended AAA-ATPase domain
11 11 SCOP 56686 Reverse transcriptase
10 10 SCOP 51487 beta-glycanases
10 10 SCOP 52641 Motor proteins
10 8 SCOP 53068 Actin/HSP70
10 10 SCOP 53721 ALDH-like
9 9 SCOP 51751 Tyrosine-dependent oxidoreductases
8 8 SCOP 47114 Nucleosome core histones
8 8 SCOP 53687 Tryptophan synthase beta subunit-like PLP-dependent enzymes
7 7 SCOP 48226 Class I alpha-1;2-mannosidase, catalytic domain
7 7 SCOP 50979 WD40-repeat
7 7 SCOP 52686 ABC transporter ATPase domain-like
6 6 SCOP 50892 Cyclophilin (peptidylprolyl isomerase)
6 6 SCOP 52318 Class I glutamine amidotransferases (GAT)
6 6 SCOP 54496 UBC-related
6 6 SCOP 56251 Proteasome subunits
6 6 SCOP 56310 Protein serine/threonine phosphatase
5 2 SCOP 48404 Ankyrin repeat
5 5 SCOP 51913 FAD-linked reductases, N-terminal domain
5 5 SCOP 52375 Class I aminoacyl-tRNA synthetases (RS), catalytic domain
5 5 SCOP 52652 Nitrogenase iron protein-like
5 5 SCOP 53384 AAT-like
5 5 SCOP 56802 Acetyl-CoA synthetase-like
5 5 SCOP 64490 RNA-polymerase beta-prime
5 5 SCOP 102609 Glycolipid 2-alpha-mannosyltransferase
4 4 SCOP 48372 Armadillo repeat
4 4 SCOP 51446 Amylase, catalytic domain
4 3 SCOP 53083 Hexokinase
4 4 SCOP 53402 Cystathionine synthase-like
4 4 SCOP 53461 UDP-glucose pyrophosphorylase
4 4 SCOP 53499 Serine carboxypeptidase-like
4 4 SCOP 55682 Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain
4 4 SCOP 56067 BC ATP-binding domain-like
4 4 SCOP 56236 Class II glutamine amidotransferases
4 4 SCOP 74771 Clathrin adaptor core protein
3 3 SCOP 48257 Citrate synthase
3 3 SCOP 49871 Osmotin, thaumatin-like protein
3 3 SCOP 49971 Glycosyl hydrolase family 7 catalytic core
3 3 SCOP 49978 Xylanase/endoglucanase 11/12
3 3 SCOP 50646 Pepsin-like
3 3 SCOP 51990 Glycosyl hydrolases family 6, cellulases
3 3 SCOP 52403 N-type ATP pyrophosphatases
3 3 SCOP 52491 Tubulin, GTPase domain
3 3 SCOP 52773 Histone deacetylase, HDAC
3 3 SCOP 53417 GABA-aminotransferase-like
3 3 SCOP 56635 Heme-dependent catalases
3 3 SCOP 63984 Sir2 family of transcriptional regulators
3 3 SCOP 64485 RNA-polymerase beta
3 3 SCOP 88760 TK-like PP module
3 3 SCOP 100948 Isochorismatase-like hydrolases
3 3 SCOP 143265 Dyp-type peroxidase-like
3 3 SCOP 143906 Gamma-glutamyltranspeptidase-like
3 3 SCOP 158782 HAT/Suf repeat
2 2 SCOP 46610 Fe,Mn superoxide dismutase (SOD), N-terminal domain
2 2 SCOP 47253 Ribonucleotide reductase-like
2 2 SCOP 47577 Calponin-homology domain, CH-domain
2 2 SCOP 48209 Glucoamylase
2 2 SCOP 48243 Terpene synthases
2 2 SCOP 48246 Protein prenyltransferases
2 2 SCOP 48385 HEAT repeat
2 2 SCOP 48453 Tetratricopeptide repeat (TPR)
2 2 SCOP 48558 L-aspartase/fumarase
2 2 SCOP 48572 HAL/PAL-like
2 2 SCOP 48577 Isoprenyl diphosphate synthases
2 2 SCOP 48580 Squalene synthase
2 2 SCOP 49448 Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
2 2 SCOP 49803 beta-Galactosidase/glucuronidase, N-terminal domain
2 2 SCOP 49999 Amine oxidase catalytic domain
2 2 SCOP 50114 C-terminal domain of ribosomal protein L2
2 2 SCOP 50461 Ribosomal protein L3
2 2 SCOP 51137 Galacturonase
2 2 SCOP 51187 Germin/Seed storage 7S protein
2 2 SCOP 51413 Inosine monophosphate dehydrogenase (IMPDH)
2 2 SCOP 51521 Family 1 of glycosyl hydrolase
2 2 SCOP 51534 Type II chitinase
2 2 SCOP 51570 Class I aldolase
2 2 SCOP 51800 Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
2 2 SCOP 51883 Aminoacid dehydrogenase-like, C-terminal domain
2 2 SCOP 51943 FAD/NAD-linked reductases, N-terminal and central domains
2 2 SCOP 52088 CRAL/TRIO domain
2 2 SCOP 52103 Crotonase-like
2 2 SCOP 52211 Succinyl-CoA synthetase domains
2 2 SCOP 52441 BC N-terminal domain-like
2 2 SCOP 52670 RecA protein-like (ATPase-domain)
2 2 SCOP 52744 Subtilases
2 2 SCOP 52778 CAT-like
2 2 SCOP 53272 Phosphoribosyltransferases (PRTases)
2 2 SCOP 53351 Arginine methyltransferase
2 2 SCOP 53525 Epoxide hydrolase
2 2 SCOP 53660 Dimeric isocitrate & isopropylmalate dehydrogenases
2 2 SCOP 53672 Aspartate/ornithine carbamoyltransferase
2 2 SCOP 53733 Aconitase iron-sulfur domain
2 2 SCOP 54002 Papain-like
2 2 SCOP 54212 Translational machinery components
2 2 SCOP 54232 GHMP Kinase, N-terminal domain
2 1 SCOP 54237 Ubiquitin-related
2 2 SCOP 55308 Tubulin, C-terminal domain
2 2 SCOP 55327 PurM N-terminal domain-like
2 2 SCOP 55363 Homoserine dehydrogenase-like
2 2 SCOP 55376 Glucose 6-phosphate dehydrogenase-like
2 2 SCOP 55505 Neurolysin-like
2 1 SCOP 55974 S-adenosylmethionine synthetase
2 2 SCOP 56043 PurM C-terminal domain-like
2 2 SCOP 56328 Lactate & malate dehydrogenases, C-terminal domain
2 2 SCOP 56530 FAH
2 2 SCOP 56646 Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains
2 2 SCOP 56742 Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
2 2 SCOP 56816 Sec1/munc18-like (SM) proteins
2 2 SCOP 57799 Casein kinase II beta subunit
2 2 SCOP 64335 Fungal zinc peptidase
2 2 SCOP 69565 Pyridoxal-dependent decarboxylase
2 2 SCOP 74789 Cullin repeat
2 2 SCOP 74911 Aldose 1-epimerase (mutarotase)
2 2 SCOP 75038 TauD/TfdA-like
2 2 SCOP 75305 Amidase signature (AS) enzymes
2 2 SCOP 75633 Cullin homology domain
2 2 SCOP 82424 Choline/Carnitine O-acyltransferase
2 2 SCOP 88704 Phosphoenolpyruvate mutase/Isocitrate lyase-like
2 2 SCOP 89494 HMGL-like
2 2 SCOP 100921 Heat shock protein 70kD (HSP70), peptide-binding domain
2 2 SCOP 111353 Ammonium transporter
2 2 SCOP 141965 PA1517-like
2 2 SCOP 158742 Trehalase-like
1 1 SCOP 46627 monodomain cytochrome c
1 1 SCOP 46676 Cytochrome bc1 domain
1 1 SCOP 46925 RNA polymerase subunit RPB10
1 1 SCOP 47204 Medium chain acyl-CoA dehydrogenase-like, C-terminal domain
1 1 SCOP 47324 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
1 1 SCOP 47502 Calmodulin-like
1 1 SCOP 47918 C-terminal domain of alpha and beta subunits of F1 ATP synthase
1 1 SCOP 47974 Ribosomal protein S7
1 1 SCOP 48351 BCR-homology GTPase activation domain (BH-domain)
1 1 SCOP 48360 p120GAP domain-like
1 1 SCOP 48440 Protein prenylyltransferase
1 1 SCOP 48446 14-3-3 protein
1 1 SCOP 48465 ENTH domain
1 1 SCOP 48543 P1 nuclease
1 1 SCOP 48593 GroEL chaperone, ATPase domain
1 1 SCOP 48604 Allosteric chorismate mutase
1 1 SCOP 49345 Cytochrome domain of cellobiose dehydrogenase
1 1 SCOP 49453 Starch-binding domain
1 1 SCOP 50023 Rieske iron-sulfur protein (ISP)
1 1 SCOP 50136 Alcohol dehydrogenase-like, N-terminal domain
1 1 SCOP 50194 Ribosomal protein L14
1 1 SCOP 50277 Myf domain
1 1 SCOP 50282 Cold shock DNA-binding domain-like
1 1 SCOP 50307 DNA ligase/mRNA capping enzyme postcatalytic domain
1 1 SCOP 50371 Ricin B-like
1 1 SCOP 50448 Elongation factors
1 1 SCOP 50466 EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
1 1 SCOP 50616 N-terminal domain of alpha and beta subunits of F1 ATP synthase
1 1 SCOP 50678 ValRS/IleRS/LeuRS editing domain
1 1 SCOP 50686 Eng V-like
1 1 SCOP 51070 Carbonic anhydrase
1 1 SCOP 51194 Homogentisate dioxygenase
1 1 SCOP 51210 cAMP-binding domain
1 1 SCOP 51339 alpha-Subunit of urease
1 1 SCOP 51352 Triosephosphate isomerase (TIM)
1 1 SCOP 51367 Histidine biosynthesis enzymes
1 1 SCOP 51375 Decarboxylase
1 1 SCOP 51557 Adenosine/AMP deaminase
1 1 SCOP 51560 alpha-subunit of urease, catalytic domain
1 1 SCOP 51594 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)
1 1 SCOP 51599 Class I DAHP synthetase
1 1 SCOP 51605 Enolase
1 1 SCOP 51714 tRNA-guanine transglycosylase
1 1 SCOP 51718 Dihydropteroate synthetase
1 1 SCOP 51727 Uroporphyrinogen decarboxylase, UROD
1 1 SCOP 51868 6-phosphogluconate dehydrogenase-like, N-terminal domain
1 1 SCOP 51931 GDI-like N domain
1 1 SCOP 51934 Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain
1 1 SCOP 52002 R1 subunit of ribonucleotide reductase, C-terminal domain
1 1 SCOP 52026 PA domain
1 1 SCOP 52052 Rna1p (RanGAP1), N-terminal domain
1 1 SCOP 52068 U2A'-like
1 1 SCOP 52122 Lumazine synthase
1 1 SCOP 52142 Uracil-DNA glycosylase
1 1 SCOP 52167 Ribosomal protein L4
1 1 SCOP 52256 N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
1 1 SCOP 52276 Rhamnogalacturonan acetylesterase
1 1 SCOP 52300 S-adenosylhomocystein hydrolase
1 1 SCOP 52314 Ribosomal protein S2
1 1 SCOP 52419 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
1 1 SCOP 52432 ETFP subunits
1 1 SCOP 52468 Deoxyhypusine synthase, DHS
1 1 SCOP 52471 C-terminal domain of the electron transfer flavoprotein alpha subunit
1 1 SCOP 52475 Pyruvate oxidase and decarboxylase, middle domain
1 1 SCOP 52513 NagB-like
1 1 SCOP 52541 Nucleotide and nucleoside kinases
1 1 SCOP 52589 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain
1 1 SCOP 52769 Arginase-like amidino hydrolases
1 1 SCOP 52901 Glutathione peroxidase-like
1 1 SCOP 52926 Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain
1 1 SCOP 52973 ITPase (Ham1)
1 1 SCOP 53045 5' to 3' exonuclease catalytic domain
1 1 SCOP 53118 DnaQ-like 3'-5' exonuclease
1 1 SCOP 53143 ERF1/Dom34 middle domain-like
1 1 SCOP 53168 Purine and uridine phosphorylases
1 1 SCOP 53201 Leucine aminopeptidase, C-terminal domain
1 1 SCOP 53204 Bacterial dinuclear zinc exopeptidases
1 1 SCOP 53224 Aminoacid dehydrogenases
1 1 SCOP 53342 Fibrillarin homologue
1 1 SCOP 53354 Protein-L-isoaspartyl O-methyltransferase
1 1 SCOP 53547 Carboxylesterase/thioesterase 1
1 1 SCOP 53614 Ribokinase-like
1 1 SCOP 53653 Arylsulfatase
1 1 SCOP 53698 double-SIS domain
1 1 SCOP 53701 Phosphoglucose isomerase, PGI
1 1 SCOP 53749 Phosphoglycerate kinase
1 1 SCOP 53766 Oligosaccharide phosphorylase
1 1 SCOP 53785 Phosphofructokinase
1 1 SCOP 53791 Tetrapyrrole methylase
1 1 SCOP 53801 Ferrochelatase
1 1 SCOP 53851 Phosphate binding protein-like
1 1 SCOP 54040 Calpain large subunit, catalytic domain (domain II)
1 1 SCOP 54054 Adenain-like
1 1 SCOP 54224 DNA gyrase/MutL, second domain
1 1 SCOP 54374 GMC oxidoreductases
1 1 SCOP 54399 GDI-like
1 1 SCOP 54827 Enolase N-terminal domain-like
1 1 SCOP 54920 Nucleoside diphosphate kinase, NDK
1 1 SCOP 54981 EF-G/eEF-2 domains III and V
1 1 SCOP 55160 eIF1-like
1 1 SCOP 55294 RPB6
1 1 SCOP 55316 L30e/L7ae ribosomal proteins
1 1 SCOP 55348 GAPDH-like
1 1 SCOP 55425 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
1 1 SCOP 55638 Cell cycle regulatory proteins
1 1 SCOP 55730 N-acetyl transferase, NAT
1 1 SCOP 55748 N-myristoyl transferase, NMT
1 1 SCOP 55832 Thymidylate synthase/dCMP hydroxymethylase
1 1 SCOP 55875 Heat shock protein 90, HSP90, N-terminal domain
1 1 SCOP 55958 Phosphoglucomutase, C-terminal domain
1 1 SCOP 55983 DNA polymerase processivity factor
1 1 SCOP 56015 Nitrite and sulphite reductase 4Fe-4S domain-like
1 1 SCOP 56092 ATP-dependent DNA ligase catalytic domain
1 1 SCOP 56105 SAICAR synthase
1 1 SCOP 56205 Hect, E3 ligase catalytic domain
1 1 SCOP 56288 Glyoxalase II (hydroxyacylglutathione hydrolase)
1 1 SCOP 56318 Nitrilase
1 1 SCOP 56323 ADC synthase
1 1 SCOP 56361 Eukaryotic DNA topoisomerase I, catalytic core
1 1 SCOP 56416 Poly(ADP-ribose) polymerase, C-terminal domain
1 1 SCOP 56426 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
1 1 SCOP 56543 Substrate-binding domain of HMG-CoA reductase
1 1 SCOP 56656 Inositol monophosphatase/fructose-1,6-bisphosphatase-like
1 1 SCOP 56720 Type II DNA topoisomerase
1 1 SCOP 56753 D-aminoacid aminotransferase-like PLP-dependent enzymes
1 1 SCOP 56797 Dehydroquinate synthase, DHQS
1 1 SCOP 56895 Aquaporin-like
1 1 SCOP 63412 MPP-like
1 1 SCOP 63611 Pumilio repeat
1 1 SCOP 63738 Leukotriene A4 hydrolase N-terminal domain
1 1 SCOP 63888 P-domain of calnexin/calreticulin
1 1 SCOP 63912 1,4-beta-N-acetylmuraminidase
1 1 SCOP 63917 Dihydroorotase
1 1 SCOP 63971 Inosicase
1 1 SCOP 63976 Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)
1 1 SCOP 63979 ATP sulfurylase catalytic domain
1 1 SCOP 64006 Undecaprenyl diphosphate synthase
1 1 SCOP 64011 ATP sulfurylase C-terminal domain
1 1 SCOP 64198 AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
1 1 SCOP 64269 PX domain
1 1 SCOP 64338 Leukotriene A4 hydrolase catalytic domain
1 1 SCOP 64357 Synatpobrevin N-terminal domain
1 1 SCOP 64372 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB
1 1 SCOP 69061 Arp2/3 complex 21 kDa subunit ARPC3
1 1 SCOP 69337 Alpha subunit of glutamate synthase, C-terminal domain
1 1 SCOP 69557 Spermidine synthase
1 1 SCOP 69573 Molybdenum cofactor biosynthesis protein MoeB
1 1 SCOP 69599 mono-SIS domain
1 1 SCOP 69602 L-histidinol dehydrogenase HisD
1 1 SCOP 69646 Arp2/3 complex subunits
1 1 SCOP 69865 Argininosuccinate synthetase, C-terminal domain
1 1 SCOP 74656 CoA transferase alpha subunit-like
1 1 SCOP 75521 Clathrin coat assembly domain
1 1 SCOP 81589 Poly(A) polymerase, PAP, N-terminal domain
1 1 SCOP 81605 PP2C-like
1 1 SCOP 81630 Poly(A) polymerase, PAP, middle domain
1 1 SCOP 82052 Obg GTP-binding protein N-terminal domain
1 1 SCOP 82115 ATP-dependent riboflavin kinase-like
1 1 SCOP 82172 DPP6 N-terminal domain-like
1 1 SCOP 82191 Acireductone dioxygenase
1 1 SCOP 82458 Trunk domain of Sec23/24
1 1 SCOP 82515 PfkB-like kinase
1 1 SCOP 82583 G domain-linked domain
1 1 SCOP 82636 MaoC-like
1 1 SCOP 82645 The homologous-pairing domain of Rad52 recombinase
1 1 SCOP 88735 TK-like Pyr module
1 1 SCOP 88741 Branched-chain alpha-keto acid dehydrogenase Pyr module
1 1 SCOP 88784 rRNA adenine dimethylase-like
1 1 SCOP 89108 Hypothetical protein YteR
1 1 SCOP 89125 Nop domain
1 1 SCOP 89503 Ketopantoate hydroxymethyltransferase PanB
1 1 SCOP 89559 NodB-like polysaccharide deacetylase
1 1 SCOP 89572 Biotin dependent carboxylase carboxyltransferase domain
1 1 SCOP 89763 Ubiquitin activating enzymes (UBA)
1 1 SCOP 89797 CoA-transferase family III (CaiB/BaiF)
1 1 SCOP 89818 Mago nashi protein
1 1 SCOP 90100 Capz beta-1 subunit
1 1 SCOP 100888 Lesion bypass DNA polymerase (Y-family), catalytic domain
1 1 SCOP 100908 MIF4G domain-like
1 1 SCOP 101407 Mo25 protein
1 1 SCOP 101448 Formin homology 2 domain (FH2 domain)
1 1 SCOP 101536 Coatomer appendage domain
1 1 SCOP 102115 Biotin synthase
1 1 SCOP 102406 MoCo carrier protein-like
1 1 SCOP 102492 CAF1-like ribonuclease
1 1 SCOP 103264 Chorismate synthase, AroC
1 1 SCOP 103379 2-methylcitrate dehydratase PrpD
1 1 SCOP 103492 Preprotein translocase SecY subunit
1 1 SCOP 103507 Mitochondrial carrier
1 1 SCOP 110020 ERO1-like
1 1 SCOP 110297 Oligoxyloglucan reducing end-specific cellobiohydrolase
1 1 SCOP 110509 NLI interacting factor-like phosphatase
1 1 SCOP 117002 Exportin HEAT-like repeat
1 1 SCOP 117111 Beta-galactosidase LacA, domains 4 and 5
1 1 SCOP 117372 YicI catalytic domain-like
1 1 SCOP 117375 Glycosyl hydrolases family 35 catalytic domain
1 1 SCOP 117449 LamB/YcsF-like
1 1 SCOP 117917 NifU C-terminal domain-like
1 1 SCOP 118076 TRAPP components
1 1 SCOP 140819 B56-like
1 1 SCOP 140963 Indoleamine 2,3-dioxygenase-like
1 1 SCOP 141436 SSRP1-like
1 1 SCOP 141636 YbiU-like
1 1 SCOP 141755 PdxS-like
1 1 SCOP 141819 PP1699/LP2961-like
1 1 SCOP 142020 Nqo1 FMN-binding domain-like
1 1 SCOP 142678 Glycine dehydrogenase subunits (GDC-P)
1 1 SCOP 142721 PyrH-like
1 1 SCOP 143001 TIM44-like
1 1 SCOP 143927 beta-CASP RNA-metabolising hydrolases
1 1 SCOP 144001 Oxysterol-binding protein
1 1 SCOP 158600 MgsA/YrvN C-terminal domain-like
1 1 SCOP 158703 Sec63 N-terminal domain
1 1 SCOP 159112 RNB domain-like
1 1 SCOP 159368 SRA domain-like
1 1 SCOP 159756 O-acetyltransferase
1 1 SCOP 160018 PFL3262-like

The following families have one or more weak hits: