2. Alpha and beta proteins (a+b)

Alpha and beta proteins (a+b) Class

Fold Superfamilies Families
Microbial ribonucleases 1 5
Lysozyme-like 1 22
Cysteine proteinases 1 49
His-Me finger endonucleases 1 6
RNase A-like 1 8
Prion-like 1 1
LysM domain 1 4
Urease, gamma-subunit 1 4
IL8-like 2 11
DNA-binding domain 1 8
Penicillin-binding protein 2x (pbp-2x), c-terminal domain 1 1
Ribosomal proteins S24e, L23 and L15e 1 3
HIT-like 2 15
Ribosomal protein S5 domain 2-like 1 33
beta-Grasp (ubiquitin-like) 14 110
FAD-linked reductases, C-terminal domain 1 7
Cystatin-like 7 85
ssDNA-binding transcriptional regulator domain 1 7
MHC antigen-recognition domain 1 13
UBC-like 1 15
Diaminopimelate epimerase-like 1 23
GFP-like 1 3
Tubby C-terminal domain-like 1 2
Pili subunits 1 10
Mitochondrial glycoprotein MAM33-like 1 2
FKBP-like 3 30
Ribosomal protein S16 1 1
Ribosomal protein S19 1 1
Ribosomal protein L31e 1 1
Allophycocyanin linker chain (domain) 1 1
Cdc48 domain 2-like 1 2
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 1 31
SecB-like 1 2
DNA-binding domain of Mlu1-box binding protein MBP1 1 1
Heme-binding protein A (HasA) 1 2
Chalcone isomerase 1 2
CBS-domain pair 1 15
Thioesterase/thiol ester dehydrase-isomerase 1 47
DLC 1 1
CI-2 family of serine protease inhibitors 1 2
alpha/beta-Hammerhead 5 13
POZ domain 1 25
EF-Ts domain-like 2 2
Fe,Mn superoxide dismutase (SOD), C-terminal domain 1 32
ClpS-like 1 3
Ribosomal L11/L12e N-terminal domain 1 1
Anti-LPS factor/recA domain 2 2
Signal recognition particle alu RNA binding heterodimer, SRP9/14 1 2
dsRBD-like 5 12
Eukaryotic type KH-domain (KH-domain type I) 1 8
Alpha-lytic protease prodomain-like 10 19
Ribosomal protein S3 C-terminal domain 1 1
Enolase N-terminal domain-like 1 78
Ribosomal protein L22 1 1
GroEL-intermediate domain like 1 2
DNA damage-inducible protein DinI 1 1
Ferredoxin-like 59 346
Ribosomal protein L30p/L7e 1 1
Probable bacterial effector-binding domain 1 5
LigT-like 1 9
Pepsin inhibitor-3 1 1
CYTH-like phosphatases 1 4
eIF1-like 2 2
Hedgehog/DD-peptidase 1 5
Alpha-L RNA-binding motif 1 5
RRF/tRNA synthetase additional domain-like 4 6
IF3-like 8 24
Yeast killer toxins 1 2
Cell division protein MinE topological specificity domain 1 1
Cyanase C-terminal domain 1 2
RuBisCO, small subunit 1 2
DCoH-like 5 13
MutS N-terminal domain-like 2 2
GYF/BRK domain-like 2 2
RL5-like 1 5
RPB5-like RNA polymerase subunit 1 1
Bacillus chorismate mutase-like 9 54
Tautomerase/MIF 1 25
FwdE/GAPDH domain-like 4 9
N domain of copper amine oxidase-like 5 7
Aha1/BPI domain-like 2 4
Subtilisin inhibitor 1 2
RNA bacteriophage capsid protein 1 1
eIF4e-like 1 10
CO dehydrogenase flavoprotein C-domain-like 2 3
SRF-like 1 1
Origin of replication-binding domain, RBD-like 1 7
FMN-dependent nitroreductase-like 1 30
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 1 2
Zincin-like 2 44
SH2-like 1 27
HPr-like 2 4
Homing endonuclease-like 2 5
T-fold 2 22
Cell cycle regulatory proteins 1 1
BLIP-like 2 4
Ribosomal protein L9 C-domain 1 1
MbtH/L9 domain-like 2 6
Ribonuclease PH domain 2-like 1 7
Regulatory factor Nef 1 3
CytB endotoxin-like 1 1
Class II aaRS and biotin synthetases 1 13
Subdomain of clathrin and coatomer appendage domain 1 2
SCP-like 1 8
Mog1p/PsbP-like 1 4
Acyl-CoA N-acyltransferases (Nat) 1 54
Gelsolin-like 3 18
Profilin-like 10 59
PR-1-like 1 4
Phoshotransferase/anion transport protein 1 7
Nudix 1 24
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain 1 1
YrdC/RibB 1 4
YbaK/ProRS associated domain 1 5
Thymidylate synthase/dCMP hydroxymethylase 1 5
N-acetylmuramoyl-L-alanine amidase-like 1 6
Cytochrome b5-like heme/steroid binding domain 1 6
DNA topoisomerase I domain 1 1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 1 20
Sporulation response regulatory protein Spo0B 1 1
Ribonuclease Rh-like 1 2
Ornithine decarboxylase C-terminal domain 1 1
Pentein, beta/alpha-propeller 1 13
Creatinase/aminopeptidase 1 4
Glutamine synthetase/guanido kinase 1 9
TBP-like 11 49
S-adenosylmethionine synthetase 1 28
DNA clamp 1 35
Molybdenum cofactor-binding domain 1 1
Nitrite and sulphite reductase 4Fe-4S domain-like 1 5
The spindle assembly checkpoint protein mad2 1 2
Phospholipase D/nuclease 1 6
Monooxygenase (hydroxylase) regulatory protein 1 1
PurM C-terminal domain-like 1 11
Ribosomal protein S8 1 1
Ribosomal protein L6 1 1
ATP-grasp 2 46
SAICAR synthase-like 1 11
Protein kinase-like (PK-like) 1 160
FAD-binding/transporter-associated domain-like 1 12
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain 1 3
Methenyltetrahydromethanopterin cyclohydrolase 1 3
Hect, E3 ligase catalytic domain 1 7
Nitrile hydratase alpha chain 1 2
4'-phosphopantetheinyl transferase 1 12
DNase I-like 1 15
Aldehyde ferredoxin oxidoreductase, N-terminal domain 1 1
Ntn hydrolase-like 2 17
DmpA/ArgJ-like 1 4
Pyruvoyl-dependent histidine and arginine decarboxylases 1 2
S-adenosylmethionine decarboxylase 1 3
Metallo-hydrolase/oxidoreductase 1 33
Metallo-dependent phosphatases 1 15
Carbon-nitrogen hydrolase 1 6
ADC synthase 1 2
LDH C-terminal domain-like 1 29
DNA breaking-rejoining enzymes 1 2
SMAD MH1 domain 1 2
Ribosome inactivating proteins (RIP) 1 7
ADP-ribosylation 1 18
Peptide deformylase 1 14
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 1 1
C-type lectin-like 1 44
SRCR-like 2 5
Fibrinogen C-terminal domain-like 1 7
gp120 core 1 1
Methionine synthase activation domain-like 1 3
Nitric oxide (NO) synthase oxygenase domain 1 1
Penicillin binding protein dimerisation domain 1 4
Oxidoreductase molybdopterin-binding domain 1 1
FAH 1 5
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains 1 1
Substrate-binding domain of HMG-CoA reductase 1 1
Conserved core of transcriptional regulatory protein vp16 1 1
Insert subdomain of RNA polymerase alpha subunit 1 1
Baseplate structural protein gp11 1 1
Major capsid protein gp5 1 1
Non-globular alpha+beta subunits of globular proteins 1 5
Prim-pol domain 1 3
LuxS/MPP-like metallohydrolase 1 6
SAND domain-like 1 2
gpW/XkdW-like 2 2
Photosystem I subunit PsaD 1 1
Prokaryotic ribosomal protein L17 1 1
PX domain 1 12
Chorismate lyase-like 1 8
YlxR-like 1 1
Hsp33 domain 1 1
CNF1/YfiH-like putative cysteine hydrolases 1 3
YopH tyrosine phosphatase N-terminal domain 1 1
Outer capsid protein sigma 3 1 1
DNA-binding domain of intron-encoded endonucleases 1 1
Protein-L-isoaspartyl O-methyltransferase, C-terminal domain 1 1
Secretion chaperone-like 5 9
MotA C-terminal domain-like 1 1
Integrin beta tail domain 1 1
SRP19 1 2
Transcription factor NusA, N-terminal domain 1 1
DsrC, the gamma subunit of dissimilatory sulfite reductase 1 1
Ribosome binding protein Y (YfiA homologue) 1 4
GTP cyclohydrolase I feedback regulatory protein, GFRP 1 1
YggU-like 1 1
Thymidylate synthase-complementing protein Thy1 1 2
MTH1598-like 1 1
LCCL domain 1 1
Argininosuccinate synthetase, C-terminal domain 1 4
beta-hairpin-alpha-hairpin repeat 2 21
TolA/TonB C-terminal domain 1 2
VSV matrix protein 1 1
Hypothetical protein MTH1880 1 1
Smc hinge domain 1 2
Rotavirus NSP2 fragment, N-terminal domain 1 2
Nucleotidyltransferase 1 21
PP2C-like 1 5
Metal cation-transporting ATPase, ATP-binding domain N 1 1
Nuclease A inhibitor (NuiA) 1 1
YbaB-like 1 3
Polo-box domain 1 3
SufE/NifU 1 8
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 1 1
GIY-YIG endonuclease 1 1
OsmC-like 1 5
Replication modulator SeqA, C-terminal DNA-binding domain 1 1
MesJ substrate recognition domain-like 1 1
Dodecin subunit-like 6 9
Receptor-binding domain of short tail fibre protein gp12 1 1
Mago nashi protein 1 1
Inhibitor of vertebrate lysozyme, Ivy 1 1
Proguanylin 1 1
FYSH domain 1 3
DNA-binding protein Tfx 1 1
Hypothetical protein YjiA, C-terminal domain 1 1
Hypothetical protein TM0875 1 1
GCM domain 1 1
Pseudouridine synthase 1 5
Lesion bypass DNA polymerase (Y-family), little finger domain 1 1
Hypothetical protein Yml108w 1 1
Ribosome binding domain-like 2 3
Obg GTP-binding protein C-terminal domain 1 1
Colicin D/E5 nuclease domain 1 2
Cell division protein ZapA-like 1 2
NSFL1 (p97 ATPase) cofactor p47, SEP domain 1 1
mRNA decapping enzyme DcpS N-terminal domain 1 1
Chromosomal protein MC1 1 1
Coproporphyrinogen III oxidase 1 2
Hypothetical protein Ta1206 1 1
Folate-binding domain 1 2
Hypothetical protein YwqG 1 1
CheC-like 1 1
Hypothetical protein YoaG 1 1
Nucleocapsid protein dimerization domain 1 2
Tombusvirus P19 core protein, VP19 1 1
Ta1353-like 1 4
Hypothetical protein TM0160 1 1
Chorismate synthase, AroC 1 2
Hypothetical protein HI1480 1 1
Suppressor of Fused, N-terminal domain 1 1
Hypothetical protein PH1602 1 2
NinB 1 1
PurS-like 1 4
Hypothetical protein MTH677 1 1
Hypothetical protein SAV1430 1 2
ParB/Sulfiredoxin 1 4
Gamma-glutamyl cyclotransferase-like 1 1
2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 1 1
HSP90 C-terminal domain 1 1
Dystroglycan, domain 2 1 1
YjbQ-like 1 4
Hypothetical protein PF0899 1 1
Hut operon positive regulatory protein HutP 1 1
Hypothetical protein yfbM 1 1
Bacillus phage protein 1 1
Ligand-binding domain in the NO signalling and Golgi transport 1 4
YggX-like 1 2
Sulfolobus fructose-1,6-bisphosphatase-like 1 1
Hemolytic lectin CEL-III, C-terminal domain 1 1
SSo0622-like 1 1
Putative modulator of DNA gyrase, PmbA/TldD 1 2
TrkA C-terminal domain-like 1 1
DNA methylase specificity domain 1 2
GTF2I-like repeat 1 8
WWE domain 1 1
AF0104/ALDC/Ptd012-like 1 7
YehU-like 1 1
DNA mismatch repair protein MutL 1 1
Phosphoprotein M1, C-terminal domain 1 2
EndoU-like 1 2
TFB5-like 1 2
YktB/PF0168-like 1 2
WGR domain-like 1 1
RelE-like 1 5
Ns1 effector domain-like 1 1
Kinetochore globular domain-like 1 2
L35p-like 1 1
Coronavirus NSP8-like 1 1
BB1717-like 1 2
TTHA1013/TTHA0281-like 1 2
NAP-like 1 4
YefM-like 1 2
Nqo5-like 1 1
THUMP domain 1 3
AMMECR1-like 1 1
VC0467-like 1 2
ImmE5-like 1 1
TM1622-like 1 1
Antiparallel beta/alpha barrel (PT-barrel) 1 2
PUG domain-like 1 1
TRCF domain-like 1 1
MK0786-like 1 2
YkuJ-like 1 1
SARS receptor-binding domain-like 1 1
TTHA1528-like 1 1
YojJ-like 1 1
STIV B116-like 1 2
PHP14-like 1 2
Phage tail protein-like 1 2
DUSP-like 1 1
L28p-like 1 2
XisI-like 1 2
DeoB insert domain-like 1 1
CorA soluble domain-like 1 1
PF0523-like 1 1
ERH-like 1 1
NE0471 N-terminal domain-like 1 1
RGC domain-like 1 1
UbiD C-terminal domain-like 1 1
IlvD/EDD N-terminal domain-like 1 1
L,D-transpeptidase pre-catalytic domain-like 1 1
YbiA-like 1 1
AF2331-like 1 1
Oxysterol-binding protein-like 1 1
ORC1-binding domain 1 1
CofE-like 1 1
Peptidoglycan deacetylase N-terminal noncatalytic region 1 1
PH1570-like 1 1
MM3350-like 1 1
GINS/PriA/YqbF domain 1 4
NRDP1 C-terminal domain-like 1 1
SARS Nsp1-like 1 1
Acetoacetate decarboxylase-like 1 3
YegP-like 1 1
CPE0013-like 1 1
YcgL-like 1 1
NMB0488-like 1 4
FlaG-like 1 1
AMPKBI-like 1 1
Shew3726-like 1 1
RplX-like 1 1
SP0830-like 1 1
NosL/MerB-like 1 2
YdfO-like 1 1
BH3703-like 1 1
PG1857-like 1 1
PB2 C-terminal domain-like 1 1
BLRF2-like 1 1
NMB0513-like 1 1
PA1123-like 1 1
Ava3019-like 1 1
SpoVG-like 1 1
EscU C-terminal domain-like 1 5
YonK-like 1 1
SMI1/KNR4-like 1 1
BTG domain-like 1 1
YehR-like 1 1
YqaI-like 1 1
gpW/gp25-like 1 1
TTHC002-like 1 1
NE1680-like 1 1
Lp2179-like 1 1
Rv2827c C-terminal domain-like 1 1
Phosphoprotein oligomerization domain-like 1 1
Taf5 N-terminal domain-like 1 1
Jann2411-like 1 1
ATP12-like 1 1
PSTPO5379-like 1 1
PG1388-like 1 1